Use of proteasome inhibitors to treat ocular disorders

Hydrocinnamate compounds that exhibit proteasome modulation activity, and in particular, proteasome inhibitory activity, can be used to topically or systemically treat ocular disorders associated withproteasome activity. The hydrocinnamate compounds can be applied to the eye, in any of a variety of ocular formulations, to treat ocular disorders, such as ocular rosacea, diabetic retinopathy, macular degeneration, and dry eye. The hydrocinnamate compounds can also be administered systemically to treat ocular disorders. 显示蛋白酶体调节活性，并且具体来说是蛋白酶体抑制活性的氢化肉桂酸酯化合物可用于局部或全身地治疗与蛋白酶体活性相关的眼部疾病。可以将氢化肉桂酸酯化合物以各种眼用制剂中的任何种施用于眼睛，以治疗眼部疾病，诸如眼部红斑痤疮、糖尿病视网膜病变、黄斑变性和干眼症。氢化肉桂酸酯化合物还可以全身给药以治疗眼部疾病。