Salbutamol impurity and impurity synthesizing method thereof

The invention discloses an impurity in starting material of salbutamol sulfate and an impurity synthesizing method. The impurity is specifically 3-(2-bromoacetyl)-2-hydroxybenzaldehyde. The impurity has the advantages that a novel reference product is provided for the detection of impurity in the starting material, crude drug and preparations thereof of the salbutamol sulfate; the quality study and quality control are favorably performed on the starting material of the salbutamol sulfate; the qualities of the crude drug and the preparation of the salbutamol sulfate can be controlled. 本发明公开了种硫酸沙丁胺醇起始物料中的杂质及杂质合成方法，该杂质具体为3-(2-溴乙酰基)-2-羟基苯甲醛。本发明公开的杂质为硫酸沙丁胺醇起始物料、原料药及其制剂中杂质的检测提供了新的对照品，更利于硫酸沙丁胺醇起始物料的质量研究与质量控制，进而控制硫酸沙丁胺醇原料药及其制剂的产品质量。