Novel synthesis method of 2-butyl-1,2-benzothiazol-3-one
The invention relates to the technical field of fine chemical engineering, and discloses a novel synthesis method of 2-butyl-1,2-benzothiazol-3-one. The method comprises the following specific steps:allowing N-butyl-2-methyl(thiobenzamide) to react with 1-chloromethyl-4-fluoro-1,4-diazoniabicyclo[2....
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| creator | CHEN ZHONGMIAO ZHANG HAO TANG TIANDI YANG KE |
| description | The invention relates to the technical field of fine chemical engineering, and discloses a novel synthesis method of 2-butyl-1,2-benzothiazol-3-one. The method comprises the following specific steps:allowing N-butyl-2-methyl(thiobenzamide) to react with 1-chloromethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate) in the presence of N,N-dimethyl-formamide for six hours at 60 DEGC, so as to obtain 2-butyl-1,2-benzothiazol-3-one. Compared with the prior art, the method has the advantages that no metal ions or chlorine-containing toxic reagents are introduced, and the yield ishigh, the operation is simple, the influence on the environment is small, the potential industrial value is achieved, and the method is worthy of popularization and application.
本发明涉及精细化工技术领域，公开种2-正丁基苯并异噻啉-3-酮的合成新方法。具体步骤：N-丁基-2-甲硫基苯甲酰胺与1-氯甲基-4-氟-1,4-重氮双环[2.2.2]辛烷双(四氟硼酸盐)在N,N-二甲基甲酰胺中60摄氏度反应6小时，即可得到2-正丁基苯并异噻啉-3-酮。同现有的技术相比，此方法无需引入金属离子或者含氯有毒试剂，产率高，操作简单，对环境影响较小，具有潜在的工业价值，值得推广应用。 |
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本发明涉及精细化工技术领域，公开种2-正丁基苯并异噻啉-3-酮的合成新方法。具体步骤：N-丁基-2-甲硫基苯甲酰胺与1-氯甲基-4-氟-1,4-重氮双环[2.2.2]辛烷双(四氟硼酸盐)在N,N-二甲基甲酰胺中60摄氏度反应6小时，即可得到2-正丁基苯并异噻啉-3-酮。同现有的技术相比，此方法无需引入金属离子或者含氯有毒试剂，产率高，操作简单，对环境影响较小，具有潜在的工业价值，值得推广应用。</description><language>chi ; eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>2018</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20181116&DB=EPODOC&CC=CN&NR=108822055A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20181116&DB=EPODOC&CC=CN&NR=108822055A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>CHEN ZHONGMIAO</creatorcontrib><creatorcontrib>ZHANG HAO</creatorcontrib><creatorcontrib>TANG TIANDI</creatorcontrib><creatorcontrib>YANG KE</creatorcontrib><title>Novel synthesis method of 2-butyl-1,2-benzothiazol-3-one</title><description>The invention relates to the technical field of fine chemical engineering, and discloses a novel synthesis method of 2-butyl-1,2-benzothiazol-3-one. The method comprises the following specific steps:allowing N-butyl-2-methyl(thiobenzamide) to react with 1-chloromethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate) in the presence of N,N-dimethyl-formamide for six hours at 60 DEGC, so as to obtain 2-butyl-1,2-benzothiazol-3-one. Compared with the prior art, the method has the advantages that no metal ions or chlorine-containing toxic reagents are introduced, and the yield ishigh, the operation is simple, the influence on the environment is small, the potential industrial value is achieved, and the method is worthy of popularization and application.
本发明涉及精细化工技术领域，公开种2-正丁基苯并异噻啉-3-酮的合成新方法。具体步骤：N-丁基-2-甲硫基苯甲酰胺与1-氯甲基-4-氟-1,4-重氮双环[2.2.2]辛烷双(四氟硼酸盐)在N,N-二甲基甲酰胺中60摄氏度反应6小时，即可得到2-正丁基苯并异噻啉-3-酮。同现有的技术相比，此方法无需引入金属离子或者含氯有毒试剂，产率高，操作简单，对环境影响较小，具有潜在的工业价值，值得推广应用。</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2018</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLDwyy9LzVEorswryUgtzixWyE0tychPUchPUzDSTSotqczRNdQBslLzqvJLMjITq_JzdI118_NSeRhY0xJzilN5oTQ3g6Kba4izh25qQX58anFBYnJqXmpJvLOfoYGFhZGRgampozExagCedC1B</recordid><startdate>20181116</startdate><enddate>20181116</enddate><creator>CHEN ZHONGMIAO</creator><creator>ZHANG HAO</creator><creator>TANG TIANDI</creator><creator>YANG KE</creator><scope>EVB</scope></search><sort><creationdate>20181116</creationdate><title>Novel synthesis method of 2-butyl-1,2-benzothiazol-3-one</title><author>CHEN ZHONGMIAO ; ZHANG HAO ; TANG TIANDI ; YANG KE</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN108822055A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2018</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>CHEN ZHONGMIAO</creatorcontrib><creatorcontrib>ZHANG HAO</creatorcontrib><creatorcontrib>TANG TIANDI</creatorcontrib><creatorcontrib>YANG KE</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>CHEN ZHONGMIAO</au><au>ZHANG HAO</au><au>TANG TIANDI</au><au>YANG KE</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Novel synthesis method of 2-butyl-1,2-benzothiazol-3-one</title><date>2018-11-16</date><risdate>2018</risdate><abstract>The invention relates to the technical field of fine chemical engineering, and discloses a novel synthesis method of 2-butyl-1,2-benzothiazol-3-one. The method comprises the following specific steps:allowing N-butyl-2-methyl(thiobenzamide) to react with 1-chloromethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate) in the presence of N,N-dimethyl-formamide for six hours at 60 DEGC, so as to obtain 2-butyl-1,2-benzothiazol-3-one. Compared with the prior art, the method has the advantages that no metal ions or chlorine-containing toxic reagents are introduced, and the yield ishigh, the operation is simple, the influence on the environment is small, the potential industrial value is achieved, and the method is worthy of popularization and application.
本发明涉及精细化工技术领域，公开种2-正丁基苯并异噻啉-3-酮的合成新方法。具体步骤：N-丁基-2-甲硫基苯甲酰胺与1-氯甲基-4-氟-1,4-重氮双环[2.2.2]辛烷双(四氟硼酸盐)在N,N-二甲基甲酰胺中60摄氏度反应6小时，即可得到2-正丁基苯并异噻啉-3-酮。同现有的技术相比，此方法无需引入金属离子或者含氯有毒试剂，产率高，操作简单，对环境影响较小，具有潜在的工业价值，值得推广应用。</abstract><oa>free_for_read</oa></addata></record> |
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| title | Novel synthesis method of 2-butyl-1,2-benzothiazol-3-one |
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