Phage capable of splitting cattle streptococcus agalactiae and application thereof

The invention discloses a streptococcus phage which can split cattle streptococcus agalactiae. The applicant names the phage as vB_SagS_FSN1; the phage is preserved in China Centre for Type Culture Collection; the preservation number is CCTCC NO:M 2017670. The streptococcus phage belongs to siphoviridae, can survive stably at the temperature of 40 to 60 DEG C and the pH of 5 to 10, has high hydrophilcity, and has very strong splitting capacity to streptococcus agalactiae, particularly cattle streptococcus agalactiae epidemic strain, in vivo or in vitro, so that the feasibility of the phage inpreventing and controlling cow mastitis caused by the streptococcus agalactiae is verified, and a new way is provided for treatment of infection of the cattle streptococcus agalactiae. 本发明公开了株可裂解牛源无乳链球菌的链球菌噬菌体，申请人将该噬菌体自命名为vB_SagS_FSN1，保存于中国典型培养物保藏中心，保藏号为CCTCC NO：M 2017670。该链球菌噬菌体属于长尾噬菌体科，在40-60℃和pH为5-10的条件下都能够稳定存活，亲水性好，在体内外对无乳链球菌尤其是牛源无乳链球菌流行株都具有很强的裂解能力，从而验证了该噬菌体在防治无乳链球菌引起的奶牛乳房炎中的可行性,为牛源无乳链球菌感染的治疗提供了新途径。