Method for efficiently and conveniently removing endotoxin of albumin solution

Method for efficiently and conveniently removing endotoxin of albumin solution

The invention discloses a method for efficiently and conveniently removing endotoxin of an albumin solution. The method comprises the steps that Triton-X114 is adopted for treating the endotoxin-containing albumin solution; albumin is recovered by means of an anion exchange chromatography. The endot...

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Hauptverfasser: WANG JIN, YE HUAHU, FA YUNZHI, YANG WEI, ZHOU XIAOJUN, BAN XING, YUAN JUFANG, LI PENGFEI
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CHEMISTRY
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ORGANIC CHEMISTRY
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creator WANG JIN
YE HUAHU
FA YUNZHI
YANG WEI
ZHOU XIAOJUN
BAN XING
YUAN JUFANG
LI PENGFEI
description The invention discloses a method for efficiently and conveniently removing endotoxin of an albumin solution. The method comprises the steps that Triton-X114 is adopted for treating the endotoxin-containing albumin solution; albumin is recovered by means of an anion exchange chromatography. The endotoxin-containing albumin solution is sequentially treated with Triton-X114 and by means of the anionexchange chromatography; compared with a method of separately adopting Triton-X114 for treatment, the method has the advantages that the efficiency of removing the endotoxin is significantly improved,the recovery rate of the albumin is effectively increased, the residual amount of the additive Triton-X114 is reduced at the same time, and the method is easy to operate, suitable for large-sample-volume treatment and capable of being scaled up to serve as an industrial production technology. By means of the method, the efficiency of removing the endotoxin is greater than 99.99%, the recovery rate of the albumin is greate
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ORGANIC CHEMISTRY
PEPTIDES
title Method for efficiently and conveniently removing endotoxin of albumin solution
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