Method for preparing daclatasvir

The invention provides a method for preparing daclatasvir and belongs to the field of pharmaceutical and chemical industry. According to the method, a compound shown in a formula II and a compound shown in a formula III are subjected to a condensation reaction, a mixture A is obtained, alkali is added, the mixture is stirred at a certain temperature, so that the mixture A reacts, an organic solvent is added for extraction and liquid separation after the reaction ends, an organic phase is concentrated and dried, and daclatasvir is obtained. The method has the characteristics that the product produced with the method has high purity, the method is high in yield, low in cost and simple to operate and the process is stable. 本发明提供了种制备达卡他韦的方法，属于医药化工领域；本发明所述方法通过将式II所示化合物与式III所示化合物进行缩合反应后，得到混合物A，然后加入碱，在定温度下搅拌，使所述混合物A发生反应，反应完毕后，加入有机溶剂进行萃取、分液，有机相浓缩干后得到达卡他韦；该方法生产得到的产物纯度高，收率高，成本低，操作简单，工艺稳定的特点。