Nanostructures comprising cobalt porphyrin-phospholipid conjugates and polyhistidine-tags

The present disclosure provides nanostructures (e.g., monolayer or bilayer nanostructures) comprising porphyrins with cobalt chelated thereto such that the cobalt metal resides within monolayer or bilayer in the porphyrin macrocycle. The nanostructures can have presentation molecules with a histidine tag attached thereto, such that at least a part of the his-tag is within the monolayer or bilayerand coordinated to the cobalt metal core and the presentation molecules are exposed to the outside of the nanostructures. The nanostructures can further comprise a cargo. The nanostructures can be used to deliver the cargo to an individual. 本公开提供了纳米结构(例如单分子层或双分子层纳米结构)，其包含卟啉(具有钴与其螯合)，使得钴金属位于卟啉大环中的单分子层或双分子层内。纳米结构可以具有呈递分子(具有与其连接的组氨酸标签)，使得至少部分的his-标签位于单分子层或双分子层内，以及与钴金属芯配位并且呈递分子暴露于纳米结构的外部。纳米结构还可以包含货物。纳米结构可用于将货物递送到个体。