Preparation method of posaconazole important intermediate
The invention provides a preparation method of a posaconazole important intermediate. A synthesis route is as follows: a formula is shown in the description. The preparation method comprises the specific preparation steps: (1) adding a compound III into an aprotic solvent; in the presence of an acid...
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| creator | YANG HANXIN SHA WEI LIANG JIANHUA MA ZONGPU LI TING |
| description | The invention provides a preparation method of a posaconazole important intermediate. A synthesis route is as follows: a formula is shown in the description. The preparation method comprises the specific preparation steps: (1) adding a compound III into an aprotic solvent; in the presence of an acid binding agent, dropwise adding benzyl chloroformate at 0 to 5 DEG C; reacting at 20 DEG C to 25 DEGC for 1h to 8h; after reacting, adding 1 to 5 times of purified water into a reaction system; crystallizing in an ice water bath for 3h to 5h; filtering and drying to obtain a compound II; (2) underthe protection of nitrogen gas, adding the compound II into toluene or ethylene glycol dimethyl ether; then adding the acid binding agent and a compound IV in sequence; carrying out reflowing reactionfor 12h to 48h; after reacting, filtering while the product is hot; crystallizing at 0 to 10 DEG C for 1h to 5h; filtering and drying to obtain the intermediate I.
种泊沙康唑重要中间体的制备方法，合成路线如下：具体制备步骤如下：（1）将化合物III加入到非质子溶剂中，在缚酸剂的存在下，在 |
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种泊沙康唑重要中间体的制备方法，合成路线如下：具体制备步骤如下：（1）将化合物III加入到非质子溶剂中，在缚酸剂的存在下，在</description><language>chi ; eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>2018</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20180123&DB=EPODOC&CC=CN&NR=107619396A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20180123&DB=EPODOC&CC=CN&NR=107619396A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>YANG HANXIN</creatorcontrib><creatorcontrib>SHA WEI</creatorcontrib><creatorcontrib>LIANG JIANHUA</creatorcontrib><creatorcontrib>MA ZONGPU</creatorcontrib><creatorcontrib>LI TING</creatorcontrib><title>Preparation method of posaconazole important intermediate</title><description>The invention provides a preparation method of a posaconazole important intermediate. A synthesis route is as follows: a formula is shown in the description. The preparation method comprises the specific preparation steps: (1) adding a compound III into an aprotic solvent; in the presence of an acid binding agent, dropwise adding benzyl chloroformate at 0 to 5 DEG C; reacting at 20 DEG C to 25 DEGC for 1h to 8h; after reacting, adding 1 to 5 times of purified water into a reaction system; crystallizing in an ice water bath for 3h to 5h; filtering and drying to obtain a compound II; (2) underthe protection of nitrogen gas, adding the compound II into toluene or ethylene glycol dimethyl ether; then adding the acid binding agent and a compound IV in sequence; carrying out reflowing reactionfor 12h to 48h; after reacting, filtering while the product is hot; crystallizing at 0 to 10 DEG C for 1h to 5h; filtering and drying to obtain the intermediate I.
种泊沙康唑重要中间体的制备方法，合成路线如下：具体制备步骤如下：（1）将化合物III加入到非质子溶剂中，在缚酸剂的存在下，在</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2018</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLAMKEotSCxKLMnMz1PITS3JyE9RyE9TKMgvTkzOz0usys9JVcjMLcgvKknMK1HIzCtJLcpNTclMLEnlYWBNS8wpTuWF0twMim6uIc4euqkF-fGpxQWJyal5qSXxzn6GBuZmhpbGlmaOxsSoAQCghC-W</recordid><startdate>20180123</startdate><enddate>20180123</enddate><creator>YANG HANXIN</creator><creator>SHA WEI</creator><creator>LIANG JIANHUA</creator><creator>MA ZONGPU</creator><creator>LI TING</creator><scope>EVB</scope></search><sort><creationdate>20180123</creationdate><title>Preparation method of posaconazole important intermediate</title><author>YANG HANXIN ; SHA WEI ; LIANG JIANHUA ; MA ZONGPU ; LI TING</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN107619396A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2018</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>YANG HANXIN</creatorcontrib><creatorcontrib>SHA WEI</creatorcontrib><creatorcontrib>LIANG JIANHUA</creatorcontrib><creatorcontrib>MA ZONGPU</creatorcontrib><creatorcontrib>LI TING</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>YANG HANXIN</au><au>SHA WEI</au><au>LIANG JIANHUA</au><au>MA ZONGPU</au><au>LI TING</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Preparation method of posaconazole important intermediate</title><date>2018-01-23</date><risdate>2018</risdate><abstract>The invention provides a preparation method of a posaconazole important intermediate. A synthesis route is as follows: a formula is shown in the description. The preparation method comprises the specific preparation steps: (1) adding a compound III into an aprotic solvent; in the presence of an acid binding agent, dropwise adding benzyl chloroformate at 0 to 5 DEG C; reacting at 20 DEG C to 25 DEGC for 1h to 8h; after reacting, adding 1 to 5 times of purified water into a reaction system; crystallizing in an ice water bath for 3h to 5h; filtering and drying to obtain a compound II; (2) underthe protection of nitrogen gas, adding the compound II into toluene or ethylene glycol dimethyl ether; then adding the acid binding agent and a compound IV in sequence; carrying out reflowing reactionfor 12h to 48h; after reacting, filtering while the product is hot; crystallizing at 0 to 10 DEG C for 1h to 5h; filtering and drying to obtain the intermediate I.
种泊沙康唑重要中间体的制备方法，合成路线如下：具体制备步骤如下：（1）将化合物III加入到非质子溶剂中，在缚酸剂的存在下，在</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY |
| title | Preparation method of posaconazole important intermediate |
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