Nanoparticle carrier containing TLR3 ligand in PRRs (pattern recognition receptors) as well as preparation method and application of nanoparticle carrier

The invention provides a nanoparticle carrier CaP/PEI/poly(I:C)/SiO2-SH containing a TLR3 ligand in PRRs (pattern recognition receptors). The compound is characterized in that calcium phosphate nanoparticles are taken as a core, the surface of the core is grafted with PEI, Poly(I:C) is adsorbed and supported on the surface of the core, a SiO2 shell is located outside the core, and under the actionof trimethoxysilane, the SiO2 shell can carry thio groups to be functionalized and can carry different fluorescent dyes such as FITC, Cy5 and the like. Further, the invention provides a preparation method and a medical application of the compound. Nanoparticles are stable in property and lower in cytotoxicity and can carry different fluorescent dyes, binding of poly(I:C) and TLR3 can be realizedeffectively with the nanoparticles as the carrier, production of interferons and proinflammatory factors is enhanced by activating a TLR3 mediated signaling pathway, and the nanoparticles are expectedto be used as drug in-vivo