Protein aggregation inhibitor
The present invention provides a protein aggregation inhibitor which can suppress protein aggregation, even if the protein is heated, and can suppress decreases in protein activity, even if the protein is further heated, the protein aggregation inhibitor characterized by comprising a sulfobetaine po...
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| creator | MATSUMURA TOSHIAKI MAEHARA KENTARO ROBIN RAJAN FURUKAWA TSUYOSHI SARUWATARI YOSHIYUKI |
| description | The present invention provides a protein aggregation inhibitor which can suppress protein aggregation, even if the protein is heated, and can suppress decreases in protein activity, even if the protein is further heated, the protein aggregation inhibitor characterized by comprising a sulfobetaine polymer resulting from polymerizing a monomer component comprising a sulfobetaine monomer representedby formula (I). (In the formula, R1 represents a hydrogen atom or a methyl group, R2 represents an alkylene group having 1 to 4 carbon atoms, R3 represents an alkyl group having 1 to 4 carbon atoms, R4 represents an alkylene group having 1 to 4 carbon atoms, and X represents an -NH- group or an -O- group.)
本发明提供即使在蛋白质被加热的情况下也能够抑制蛋白质的凝聚、并且即使在蛋白质被加热的情况下也能够抑制蛋白质的活性降低的蛋白质凝聚抑制剂，其中，该蛋白质凝聚抑制剂含有使包含式(I)所示的磺基甜菜碱单体的单体成分聚合而成的磺基甜菜碱聚合物(式(I)中，R表示氢原子或甲基，R表示碳原子数1～4的亚烷基，R表示碳原子数1～4的烷基，R表示碳原子数1～4的亚烷基，X表示-NH-基或-O-基)。 |
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本发明提供即使在蛋白质被加热的情况下也能够抑制蛋白质的凝聚、并且即使在蛋白质被加热的情况下也能够抑制蛋白质的活性降低的蛋白质凝聚抑制剂，其中，该蛋白质凝聚抑制剂含有使包含式(I)所示的磺基甜菜碱单体的单体成分聚合而成的磺基甜菜碱聚合物(式(I)中，R表示氢原子或甲基，R表示碳原子数1～4的亚烷基，R表示碳原子数1～4的烷基，R表示碳原子数1～4的亚烷基，X表示-NH-基或-O-基)。</description><language>chi ; eng</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS BASED THEREON ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; FOODS OR FOODSTUFFS ; HUMAN NECESSITIES ; MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVINGCARBON-TO-CARBON UNSATURATED BONDS ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; ORGANIC CHEMISTRY ; ORGANIC MACROMOLECULAR COMPOUNDS ; PEPTIDES ; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; PROTEIN COMPOSITIONS FOR FOODSTUFFS ; SPIRITS ; THEIR PREPARATION OR CHEMICAL WORKING-UP ; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES ; VINEGAR ; WINE ; WORKING-UP PROTEINS FOR FOODSTUFFS</subject><creationdate>2018</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20180102&DB=EPODOC&CC=CN&NR=107531748A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76419</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20180102&DB=EPODOC&CC=CN&NR=107531748A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>MATSUMURA TOSHIAKI</creatorcontrib><creatorcontrib>MAEHARA KENTARO</creatorcontrib><creatorcontrib>ROBIN RAJAN</creatorcontrib><creatorcontrib>FURUKAWA TSUYOSHI</creatorcontrib><creatorcontrib>SARUWATARI YOSHIYUKI</creatorcontrib><title>Protein aggregation inhibitor</title><description>The present invention provides a protein aggregation inhibitor which can suppress protein aggregation, even if the protein is heated, and can suppress decreases in protein activity, even if the protein is further heated, the protein aggregation inhibitor characterized by comprising a sulfobetaine polymer resulting from polymerizing a monomer component comprising a sulfobetaine monomer representedby formula (I). (In the formula, R1 represents a hydrogen atom or a methyl group, R2 represents an alkylene group having 1 to 4 carbon atoms, R3 represents an alkyl group having 1 to 4 carbon atoms, R4 represents an alkylene group having 1 to 4 carbon atoms, and X represents an -NH- group or an -O- group.)
本发明提供即使在蛋白质被加热的情况下也能够抑制蛋白质的凝聚、并且即使在蛋白质被加热的情况下也能够抑制蛋白质的活性降低的蛋白质凝聚抑制剂，其中，该蛋白质凝聚抑制剂含有使包含式(I)所示的磺基甜菜碱单体的单体成分聚合而成的磺基甜菜碱聚合物(式(I)中，R表示氢原子或甲基，R表示碳原子数1～4的亚烷基，R表示碳原子数1～4的烷基，R表示碳原子数1～4的亚烷基，X表示-NH-基或-O-基)。</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS BASED THEREON</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>FOODS OR FOODSTUFFS</subject><subject>HUMAN NECESSITIES</subject><subject>MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVINGCARBON-TO-CARBON UNSATURATED BONDS</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>ORGANIC CHEMISTRY</subject><subject>ORGANIC MACROMOLECULAR COMPOUNDS</subject><subject>PEPTIDES</subject><subject>PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>PROTEIN COMPOSITIONS FOR FOODSTUFFS</subject><subject>SPIRITS</subject><subject>THEIR PREPARATION OR CHEMICAL WORKING-UP</subject><subject>THEIR TREATMENT, NOT COVERED BY OTHER CLASSES</subject><subject>VINEGAR</subject><subject>WINE</subject><subject>WORKING-UP PROTEINS FOR FOODSTUFFS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2018</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZJANKMovSc3MU0hMTy9KTU8syczPU8jMy8hMyizJL-JhYE1LzClO5YXS3AyKbq4hzh66qQX58anFBYnJqXmpJfHOfoYG5qbGhuYmFo7GxKgBAO4yJH0</recordid><startdate>20180102</startdate><enddate>20180102</enddate><creator>MATSUMURA TOSHIAKI</creator><creator>MAEHARA KENTARO</creator><creator>ROBIN RAJAN</creator><creator>FURUKAWA TSUYOSHI</creator><creator>SARUWATARI YOSHIYUKI</creator><scope>EVB</scope></search><sort><creationdate>20180102</creationdate><title>Protein aggregation inhibitor</title><author>MATSUMURA TOSHIAKI ; MAEHARA KENTARO ; ROBIN RAJAN ; FURUKAWA TSUYOSHI ; SARUWATARI YOSHIYUKI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN107531748A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2018</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS BASED THEREON</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>FOODS OR FOODSTUFFS</topic><topic>HUMAN NECESSITIES</topic><topic>MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVINGCARBON-TO-CARBON UNSATURATED BONDS</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>ORGANIC CHEMISTRY</topic><topic>ORGANIC MACROMOLECULAR COMPOUNDS</topic><topic>PEPTIDES</topic><topic>PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>PROTEIN COMPOSITIONS FOR FOODSTUFFS</topic><topic>SPIRITS</topic><topic>THEIR PREPARATION OR CHEMICAL WORKING-UP</topic><topic>THEIR TREATMENT, NOT COVERED BY OTHER CLASSES</topic><topic>VINEGAR</topic><topic>WINE</topic><topic>WORKING-UP PROTEINS FOR FOODSTUFFS</topic><toplevel>online_resources</toplevel><creatorcontrib>MATSUMURA TOSHIAKI</creatorcontrib><creatorcontrib>MAEHARA KENTARO</creatorcontrib><creatorcontrib>ROBIN RAJAN</creatorcontrib><creatorcontrib>FURUKAWA TSUYOSHI</creatorcontrib><creatorcontrib>SARUWATARI YOSHIYUKI</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>MATSUMURA TOSHIAKI</au><au>MAEHARA KENTARO</au><au>ROBIN RAJAN</au><au>FURUKAWA TSUYOSHI</au><au>SARUWATARI YOSHIYUKI</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Protein aggregation inhibitor</title><date>2018-01-02</date><risdate>2018</risdate><abstract>The present invention provides a protein aggregation inhibitor which can suppress protein aggregation, even if the protein is heated, and can suppress decreases in protein activity, even if the protein is further heated, the protein aggregation inhibitor characterized by comprising a sulfobetaine polymer resulting from polymerizing a monomer component comprising a sulfobetaine monomer representedby formula (I). (In the formula, R1 represents a hydrogen atom or a methyl group, R2 represents an alkylene group having 1 to 4 carbon atoms, R3 represents an alkyl group having 1 to 4 carbon atoms, R4 represents an alkylene group having 1 to 4 carbon atoms, and X represents an -NH- group or an -O- group.)
本发明提供即使在蛋白质被加热的情况下也能够抑制蛋白质的凝聚、并且即使在蛋白质被加热的情况下也能够抑制蛋白质的活性降低的蛋白质凝聚抑制剂，其中，该蛋白质凝聚抑制剂含有使包含式(I)所示的磺基甜菜碱单体的单体成分聚合而成的磺基甜菜碱聚合物(式(I)中，R表示氢原子或甲基，R表示碳原子数1～4的亚烷基，R表示碳原子数1～4的烷基，R表示碳原子数1～4的亚烷基，X表示-NH-基或-O-基)。</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS BASED THEREON COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FOODS OR FOODSTUFFS HUMAN NECESSITIES MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVINGCARBON-TO-CARBON UNSATURATED BONDS METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY ORGANIC MACROMOLECULAR COMPOUNDS PEPTIDES PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS PROTEIN COMPOSITIONS FOR FOODSTUFFS SPIRITS THEIR PREPARATION OR CHEMICAL WORKING-UP THEIR TREATMENT, NOT COVERED BY OTHER CLASSES VINEGAR WINE WORKING-UP PROTEINS FOR FOODSTUFFS |
| title | Protein aggregation inhibitor |
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