Molecular markers for diagnosing active tuberculous diseases and application thereof
The invention discloses molecular makers for diagnosing active tuberculous diseases and applications thereof. The invention proves that miR-16, B12 and CD272 can be used as the molecular markers for diagnosing the active tuberculous diseases, diagnosis with a combination of the three can improve the...
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| creator | LIN DONGZI LIN BIHUA LIU XINGUANG YUAN YAOQIN ZHANG HAITAO ZENG JINCHENG ZHOU KEYUAN LIU QIANKUN HUANG MINGYUAN MEI YUEZHI |
| description | The invention discloses molecular makers for diagnosing active tuberculous diseases and applications thereof. The invention proves that miR-16, B12 and CD272 can be used as the molecular markers for diagnosing the active tuberculous diseases, diagnosis with a combination of the three can improve the diagnosis accuracy rate (more than 90%) of the tuberculous diseases, and the diagnosis accuracy rate is far superior to that of diagnosis with a single marker, so that the molecular markers are suitable for screening, diagnosis and efficacy evaluation for the active tuberculous diseases.
本发明公开了用于诊断活动性结核类疾病的分子标志物及其应用。本发明证实了miR-16、B12、CD272可作为诊断活动性结核类疾病的分子标志物，并且三者组合诊断能够提高结核病的诊断准确率(＞90％)，远远优于单标志物诊断，适用于活动性结核类疾病筛查、诊断和药效评价。 |
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本发明公开了用于诊断活动性结核类疾病的分子标志物及其应用。本发明证实了miR-16、B12、CD272可作为诊断活动性结核类疾病的分子标志物，并且三者组合诊断能够提高结核病的诊断准确率(＞90％)，远远优于单标志物诊断，适用于活动性结核类疾病筛查、诊断和药效评价。</description><language>chi ; eng</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS OR TEST PAPERS THEREFOR ; COMPOSITIONS THEREOF ; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ; CULTURE MEDIA ; ENZYMOLOGY ; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; PROCESSES OF PREPARING SUCH COMPOSITIONS ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2017</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20171208&DB=EPODOC&CC=CN&NR=107447042A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,309,781,886,25569,76552</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20171208&DB=EPODOC&CC=CN&NR=107447042A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>LIN DONGZI</creatorcontrib><creatorcontrib>LIN BIHUA</creatorcontrib><creatorcontrib>LIU XINGUANG</creatorcontrib><creatorcontrib>YUAN YAOQIN</creatorcontrib><creatorcontrib>ZHANG HAITAO</creatorcontrib><creatorcontrib>ZENG JINCHENG</creatorcontrib><creatorcontrib>ZHOU KEYUAN</creatorcontrib><creatorcontrib>LIU QIANKUN</creatorcontrib><creatorcontrib>HUANG MINGYUAN</creatorcontrib><creatorcontrib>MEI YUEZHI</creatorcontrib><title>Molecular markers for diagnosing active tuberculous diseases and application thereof</title><description>The invention discloses molecular makers for diagnosing active tuberculous diseases and applications thereof. The invention proves that miR-16, B12 and CD272 can be used as the molecular markers for diagnosing the active tuberculous diseases, diagnosis with a combination of the three can improve the diagnosis accuracy rate (more than 90%) of the tuberculous diseases, and the diagnosis accuracy rate is far superior to that of diagnosis with a single marker, so that the molecular markers are suitable for screening, diagnosis and efficacy evaluation for the active tuberculous diseases.
本发明公开了用于诊断活动性结核类疾病的分子标志物及其应用。本发明证实了miR-16、B12、CD272可作为诊断活动性结核类疾病的分子标志物，并且三者组合诊断能够提高结核病的诊断准确率(＞90％)，远远优于单标志物诊断，适用于活动性结核类疾病筛查、诊断和药效评价。</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS OR TEST PAPERS THEREFOR</subject><subject>COMPOSITIONS THEREOF</subject><subject>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>PROCESSES OF PREPARING SUCH COMPOSITIONS</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2017</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNyjEOwjAQBVE3FAi4w3IApACRUqMIRANV-mhxfoKF8Vpem_OTggNQTTFvabqbeNjiOdGb0wtJaZREg-MpiLowEdvsPqBcHkgzlKLzVbBCicNAHKN3lrOTQPmJBBnXZjGyV2x-XZnt5dy11x2i9NDIFgG5b-_7qqnrpqoPp-M_5gv_YDmW</recordid><startdate>20171208</startdate><enddate>20171208</enddate><creator>LIN DONGZI</creator><creator>LIN BIHUA</creator><creator>LIU XINGUANG</creator><creator>YUAN YAOQIN</creator><creator>ZHANG HAITAO</creator><creator>ZENG JINCHENG</creator><creator>ZHOU KEYUAN</creator><creator>LIU QIANKUN</creator><creator>HUANG MINGYUAN</creator><creator>MEI YUEZHI</creator><scope>EVB</scope></search><sort><creationdate>20171208</creationdate><title>Molecular markers for diagnosing active tuberculous diseases and application thereof</title><author>LIN DONGZI ; LIN BIHUA ; LIU XINGUANG ; YUAN YAOQIN ; ZHANG HAITAO ; ZENG JINCHENG ; ZHOU KEYUAN ; LIU QIANKUN ; HUANG MINGYUAN ; MEI YUEZHI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN107447042A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2017</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS OR TEST PAPERS THEREFOR</topic><topic>COMPOSITIONS THEREOF</topic><topic>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>PROCESSES OF PREPARING SUCH COMPOSITIONS</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>LIN DONGZI</creatorcontrib><creatorcontrib>LIN BIHUA</creatorcontrib><creatorcontrib>LIU XINGUANG</creatorcontrib><creatorcontrib>YUAN YAOQIN</creatorcontrib><creatorcontrib>ZHANG HAITAO</creatorcontrib><creatorcontrib>ZENG JINCHENG</creatorcontrib><creatorcontrib>ZHOU KEYUAN</creatorcontrib><creatorcontrib>LIU QIANKUN</creatorcontrib><creatorcontrib>HUANG MINGYUAN</creatorcontrib><creatorcontrib>MEI YUEZHI</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>LIN DONGZI</au><au>LIN BIHUA</au><au>LIU XINGUANG</au><au>YUAN YAOQIN</au><au>ZHANG HAITAO</au><au>ZENG JINCHENG</au><au>ZHOU KEYUAN</au><au>LIU QIANKUN</au><au>HUANG MINGYUAN</au><au>MEI YUEZHI</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Molecular markers for diagnosing active tuberculous diseases and application thereof</title><date>2017-12-08</date><risdate>2017</risdate><abstract>The invention discloses molecular makers for diagnosing active tuberculous diseases and applications thereof. The invention proves that miR-16, B12 and CD272 can be used as the molecular markers for diagnosing the active tuberculous diseases, diagnosis with a combination of the three can improve the diagnosis accuracy rate (more than 90%) of the tuberculous diseases, and the diagnosis accuracy rate is far superior to that of diagnosis with a single marker, so that the molecular markers are suitable for screening, diagnosis and efficacy evaluation for the active tuberculous diseases.
本发明公开了用于诊断活动性结核类疾病的分子标志物及其应用。本发明证实了miR-16、B12、CD272可作为诊断活动性结核类疾病的分子标志物，并且三者组合诊断能够提高结核病的诊断准确率(＞90％)，远远优于单标志物诊断，适用于活动性结核类疾病筛查、诊断和药效评价。</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE |
| title | Molecular markers for diagnosing active tuberculous diseases and application thereof |
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