Molecular markers for diagnosing active tuberculous diseases and application thereof

The invention discloses molecular makers for diagnosing active tuberculous diseases and applications thereof. The invention proves that miR-16, B12 and CD272 can be used as the molecular markers for diagnosing the active tuberculous diseases, diagnosis with a combination of the three can improve the diagnosis accuracy rate (more than 90%) of the tuberculous diseases, and the diagnosis accuracy rate is far superior to that of diagnosis with a single marker, so that the molecular markers are suitable for screening, diagnosis and efficacy evaluation for the active tuberculous diseases. 本发明公开了用于诊断活动性结核类疾病的分子标志物及其应用。本发明证实了miR-16、B12、CD272可作为诊断活动性结核类疾病的分子标志物，并且三者组合诊断能够提高结核病的诊断准确率(＞90％)，远远优于单标志物诊断，适用于活动性结核类疾病筛查、诊断和药效评价。