COPOLYMERS AS EXCIPIENTS FOR EFFECTIVE SOLUBILIZATION OF POORLY WATER-SOLUBLE SUBSTANCES FROM SOLID MIXTURES
The present invention relates to the use of uncrosslinked copolymers having a backbone comprising i) a plurality of thermo-responsive structural units derived from one or more than one N-alkyl or N,N-dialkyl substituted (alkyl)acrylamide monomer and ii) a plurality of hydrophilic structural units de...
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| creator | GUO LI TING JEFFREY M WIDANAPATHIRANA LAKMINI TALE SWAPNIL GUILLAUDEU STEVEN J BATES FRANK S REINEKE THERESA M |
| description | The present invention relates to the use of uncrosslinked copolymers having a backbone comprising i) a plurality of thermo-responsive structural units derived from one or more than one N-alkyl or N,N-dialkyl substituted (alkyl)acrylamide monomer and ii) a plurality of hydrophilic structural units derived from one or more than one second ethylenically unsaturated monomer as excipients in solid mixtures with poorly water-soluble substances for effective solubilization of the latter in aqueous media. Solid dosage forms comprising a solid mixture of such copolymer(s) and poorly water-soluble substance(s) are also within the scope of the invention.
本发明涉及具有主链的非交联共聚物作为在具有不良水溶性物质的固体混合物中用于所述不良水溶性物质在水性介质中的有效增溶的赋形剂的用途，所述主链包含i)衍生自种或多于种N-烷基或N,N-二烷基取代的(烷基)丙烯酰胺单体的多个热响应性结构单元和ii)衍生自种或多于种第二烯系不饱和单体的多个亲水性结构单元。包含这类共聚物和不良水溶性物质的固体混合物的固体剂型也在本发明的范围内。 |
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本发明涉及具有主链的非交联共聚物作为在具有不良水溶性物质的固体混合物中用于所述不良水溶性物质在水性介质中的有效增溶的赋形剂的用途，所述主链包含i)衍生自种或多于种N-烷基或N,N-二烷基取代的(烷基)丙烯酰胺单体的多个热响应性结构单元和ii)衍生自种或多于种第二烯系不饱和单体的多个亲水性结构单元。包含这类共聚物和不良水溶性物质的固体混合物的固体剂型也在本发明的范围内。</description><language>chi ; eng</language><subject>CHEMISTRY ; COMPOSITIONS BASED THEREON ; HUMAN NECESSITIES ; HYGIENE ; MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVINGCARBON-TO-CARBON UNSATURATED BONDS ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC MACROMOLECULAR COMPOUNDS ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; THEIR PREPARATION OR CHEMICAL WORKING-UP</subject><creationdate>2017</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20171128&DB=EPODOC&CC=CN&NR=107406556A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20171128&DB=EPODOC&CC=CN&NR=107406556A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>GUO LI</creatorcontrib><creatorcontrib>TING JEFFREY M</creatorcontrib><creatorcontrib>WIDANAPATHIRANA LAKMINI</creatorcontrib><creatorcontrib>TALE SWAPNIL</creatorcontrib><creatorcontrib>GUILLAUDEU STEVEN J</creatorcontrib><creatorcontrib>BATES FRANK S</creatorcontrib><creatorcontrib>REINEKE THERESA M</creatorcontrib><title>COPOLYMERS AS EXCIPIENTS FOR EFFECTIVE SOLUBILIZATION OF POORLY WATER-SOLUBLE SUBSTANCES FROM SOLID MIXTURES</title><description>The present invention relates to the use of uncrosslinked copolymers having a backbone comprising i) a plurality of thermo-responsive structural units derived from one or more than one N-alkyl or N,N-dialkyl substituted (alkyl)acrylamide monomer and ii) a plurality of hydrophilic structural units derived from one or more than one second ethylenically unsaturated monomer as excipients in solid mixtures with poorly water-soluble substances for effective solubilization of the latter in aqueous media. Solid dosage forms comprising a solid mixture of such copolymer(s) and poorly water-soluble substance(s) are also within the scope of the invention.
本发明涉及具有主链的非交联共聚物作为在具有不良水溶性物质的固体混合物中用于所述不良水溶性物质在水性介质中的有效增溶的赋形剂的用途，所述主链包含i)衍生自种或多于种N-烷基或N,N-二烷基取代的(烷基)丙烯酰胺单体的多个热响应性结构单元和ii)衍生自种或多于种第二烯系不饱和单体的多个亲水性结构单元。包含这类共聚物和不良水溶性物质的固体混合物的固体剂型也在本发明的范围内。</description><subject>CHEMISTRY</subject><subject>COMPOSITIONS BASED THEREON</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVINGCARBON-TO-CARBON UNSATURATED BONDS</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC MACROMOLECULAR COMPOUNDS</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>THEIR PREPARATION OR CHEMICAL WORKING-UP</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2017</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNi0EOgjAQALl4MOof1geQYBQ4l7qNm5QuaYuCF0JMPRElwf9HND7A0xxmZhkNkivWbYnWgXCAjaSK0HgHii2gUig9nREc67ogTVfhiQ2wgorZ6hYuwqONv1rPWV04L4zE-bdcfjY6QkmNry26dbS498MUNj-uoq1CL09xGJ9dmMb-Fh7h1UmzS_JDkqVpJvb_NG9tTDeP</recordid><startdate>20171128</startdate><enddate>20171128</enddate><creator>GUO LI</creator><creator>TING JEFFREY M</creator><creator>WIDANAPATHIRANA LAKMINI</creator><creator>TALE SWAPNIL</creator><creator>GUILLAUDEU STEVEN J</creator><creator>BATES FRANK S</creator><creator>REINEKE THERESA M</creator><scope>EVB</scope></search><sort><creationdate>20171128</creationdate><title>COPOLYMERS AS EXCIPIENTS FOR EFFECTIVE SOLUBILIZATION OF POORLY WATER-SOLUBLE SUBSTANCES FROM SOLID MIXTURES</title><author>GUO LI ; TING JEFFREY M ; WIDANAPATHIRANA LAKMINI ; TALE SWAPNIL ; GUILLAUDEU STEVEN J ; BATES FRANK S ; REINEKE THERESA M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN107406556A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2017</creationdate><topic>CHEMISTRY</topic><topic>COMPOSITIONS BASED THEREON</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVINGCARBON-TO-CARBON UNSATURATED BONDS</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC MACROMOLECULAR COMPOUNDS</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>THEIR PREPARATION OR CHEMICAL WORKING-UP</topic><toplevel>online_resources</toplevel><creatorcontrib>GUO LI</creatorcontrib><creatorcontrib>TING JEFFREY M</creatorcontrib><creatorcontrib>WIDANAPATHIRANA LAKMINI</creatorcontrib><creatorcontrib>TALE SWAPNIL</creatorcontrib><creatorcontrib>GUILLAUDEU STEVEN J</creatorcontrib><creatorcontrib>BATES FRANK S</creatorcontrib><creatorcontrib>REINEKE THERESA M</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>GUO LI</au><au>TING JEFFREY M</au><au>WIDANAPATHIRANA LAKMINI</au><au>TALE SWAPNIL</au><au>GUILLAUDEU STEVEN J</au><au>BATES FRANK S</au><au>REINEKE THERESA M</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>COPOLYMERS AS EXCIPIENTS FOR EFFECTIVE SOLUBILIZATION OF POORLY WATER-SOLUBLE SUBSTANCES FROM SOLID MIXTURES</title><date>2017-11-28</date><risdate>2017</risdate><abstract>The present invention relates to the use of uncrosslinked copolymers having a backbone comprising i) a plurality of thermo-responsive structural units derived from one or more than one N-alkyl or N,N-dialkyl substituted (alkyl)acrylamide monomer and ii) a plurality of hydrophilic structural units derived from one or more than one second ethylenically unsaturated monomer as excipients in solid mixtures with poorly water-soluble substances for effective solubilization of the latter in aqueous media. Solid dosage forms comprising a solid mixture of such copolymer(s) and poorly water-soluble substance(s) are also within the scope of the invention.
本发明涉及具有主链的非交联共聚物作为在具有不良水溶性物质的固体混合物中用于所述不良水溶性物质在水性介质中的有效增溶的赋形剂的用途，所述主链包含i)衍生自种或多于种N-烷基或N,N-二烷基取代的(烷基)丙烯酰胺单体的多个热响应性结构单元和ii)衍生自种或多于种第二烯系不饱和单体的多个亲水性结构单元。包含这类共聚物和不良水溶性物质的固体混合物的固体剂型也在本发明的范围内。</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY COMPOSITIONS BASED THEREON HUMAN NECESSITIES HYGIENE MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVINGCARBON-TO-CARBON UNSATURATED BONDS MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC MACROMOLECULAR COMPOUNDS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES THEIR PREPARATION OR CHEMICAL WORKING-UP |
| title | COPOLYMERS AS EXCIPIENTS FOR EFFECTIVE SOLUBILIZATION OF POORLY WATER-SOLUBLE SUBSTANCES FROM SOLID MIXTURES |
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