7,8-dimethoxy-2,3,4,5-tetrahydro-1H-benzo[c]azepine hydrochloride and preparation method thereof

7,8-dimethoxy-2,3,4,5-tetrahydro-1H-benzo[c]azepine hydrochloride and preparation method thereof

The invention discloses 7,8-dimethoxy-2,3,4,5-tetrahydro-1H-benzo[c]azepine hydrochloride and a preparation method thereof. The method comprises the following steps: taking 3,4-dimethoxyhydrocinnamic acid as a starting material, catalyzing by thionyl chloride and then carrying out aminolysis treatme...

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Hauptverfasser: JIN QINGXIAN, CHEN SHUYU, QIAO WENJUN, ZHANG HONGPEI, FANG SHAOMING, ZHEN YAOYAO
Format: Patent
Sprache:chi ; eng
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CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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creator JIN QINGXIAN
CHEN SHUYU
QIAO WENJUN
ZHANG HONGPEI
FANG SHAOMING
ZHEN YAOYAO
description The invention discloses 7,8-dimethoxy-2,3,4,5-tetrahydro-1H-benzo[c]azepine hydrochloride and a preparation method thereof. The method comprises the following steps: taking 3,4-dimethoxyhydrocinnamic acid as a starting material, catalyzing by thionyl chloride and then carrying out aminolysis treatment to obtain 3,4-dimethoxyphenyl propanamide; carrying out reductive treatment by boron trifluoride diethyl etherate and sodium borohydride to obtain 3,4-dimethoxy-amphetamine; carrying out reaction on the 3,4-dimethoxy-amphetamine in sulfuric acid and paraformaldehyde to obtain N-acetyl-7,8-dimethoxy-2,3,4,5-tetrahydro-1H-benzo[c]azepine after acetyl protection; carrying out acetyl deprotection and Boc deprotection to obtain N-Boc-7,8-dimethoxy-2,3,4,5-tetrahydro-1H-benzo[c]azepine; introducing hydrochloric acid gas to obtain the 7,8-dimethoxy-2,3,4,5-tetrahydro-1H-benzo[c]azepine hydrochloride. The preparation method is relative mild in conditions, and a product is easy to process and purify, and is suitable for
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METALLURGY
ORGANIC CHEMISTRY
title 7,8-dimethoxy-2,3,4,5-tetrahydro-1H-benzo[c]azepine hydrochloride and preparation method thereof
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