VEGF antibody-carrying ophthalmic thermosensitive hydrogel implant and preparation method thereof

The invention provides a VEGF antibody-carrying ophthalmic thermosensitive hydrogel implant and a preparation method thereof, and relates to a medical preparation and a preparation method thereof. The implant is a thermosensitive hydrogel for ophthalmic injection, and the phase change temperature of the thermosensitive hydrogel is 34DEG C-35DEG C; the thermosensitive hydrogel is selected from a thermosensitive NIPAAm hydrogel and carries a VEGF antibody; and the mass concentration of a thermosensitive hydrogel solution is 10%-20%. According to the VEGF antibody-carrying ophthalmic thermosensitive hydrogel implant, an anti-VEGF monoclonal antibody drug is slowly released, a relatively noninvasive method is used, the anti-VEGF monoclonal antibody drug and a gel are uniformly mixed to prepare a gel system which presents a liquid state in vitro and quickly changes into a semisolid state when injected into eyeballs, so the drug arrives the posterior segment through the injection mode to achieve the effect of local