Preparation method of 5-chloro-6-(chloromethyl)-2,4-(1H,3H)-pyrimidinedione
The patent provides a preparation method of 5-chloro-6-(chloromethyl)-2,4-(1H,3H)-pyrimidinedione. Orotic acid, which is used as a starting material, undergoes alpha-hydrogen chlorination; then, carboxyl is directly reduced to hydroxymethyl; and a chlorination replacement reaction is carried out. Th...
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| creator | XIE SUQIONG CHEN GONG SONG XUE |
| description | The patent provides a preparation method of 5-chloro-6-(chloromethyl)-2,4-(1H,3H)-pyrimidinedione. Orotic acid, which is used as a starting material, undergoes alpha-hydrogen chlorination; then, carboxyl is directly reduced to hydroxymethyl; and a chlorination replacement reaction is carried out. Through the three-step reactions, the target product is obtained. The preparation method of the invention is simple to operate, has stable process, has high yield, is low-cost, and is suitable for industrial production.
本专利提供种5-氯-6-氯甲基-2，4-(1H，3H)-嘧啶二酮的制备方法，以乳清酸为起始原料，通过α氢的氯代反应，再直接还原羧基为羟甲基，并进行氯化置换反应等三步反应，得到目标产物。本发明操作简单，工艺稳定，产率高，成本低，适合工业生产。 |
| format | Patent |
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本专利提供种5-氯-6-氯甲基-2，4-(1H，3H)-嘧啶二酮的制备方法，以乳清酸为起始原料，通过α氢的氯代反应，再直接还原羧基为羟甲基，并进行氯化置换反应等三步反应，得到目标产物。本发明操作简单，工艺稳定，产率高，成本低，适合工业生产。</description><language>chi ; eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>2017</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20170901&DB=EPODOC&CC=CN&NR=107118164A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20170901&DB=EPODOC&CC=CN&NR=107118164A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>XIE SUQIONG</creatorcontrib><creatorcontrib>CHEN GONG</creatorcontrib><creatorcontrib>SONG XUE</creatorcontrib><title>Preparation method of 5-chloro-6-(chloromethyl)-2,4-(1H,3H)-pyrimidinedione</title><description>The patent provides a preparation method of 5-chloro-6-(chloromethyl)-2,4-(1H,3H)-pyrimidinedione. Orotic acid, which is used as a starting material, undergoes alpha-hydrogen chlorination; then, carboxyl is directly reduced to hydroxymethyl; and a chlorination replacement reaction is carried out. Through the three-step reactions, the target product is obtained. The preparation method of the invention is simple to operate, has stable process, has high yield, is low-cost, and is suitable for industrial production.
本专利提供种5-氯-6-氯甲基-2，4-(1H，3H)-嘧啶二酮的制备方法，以乳清酸为起始原料，通过α氢的氯代反应，再直接还原羧基为羟甲基，并进行氯化置换反应等三步反应，得到目标产物。本发明操作简单，工艺稳定，产率高，成本低，适合工业生产。</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2017</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZPAOKEotSCxKLMnMz1PITS3JyE9RyE9TMNVNzsjJL8rXNdPVgLBAcpU5mrpGOia6GoYeOsYemroFlUWZuZkpmXmpKUDtqTwMrGmJOcWpvFCam0HRzTXE2UM3tSA_PrW4IDE5NS-1JN7Zz9DA3NDQwtDMxNGYGDUATegzHg</recordid><startdate>20170901</startdate><enddate>20170901</enddate><creator>XIE SUQIONG</creator><creator>CHEN GONG</creator><creator>SONG XUE</creator><scope>EVB</scope></search><sort><creationdate>20170901</creationdate><title>Preparation method of 5-chloro-6-(chloromethyl)-2,4-(1H,3H)-pyrimidinedione</title><author>XIE SUQIONG ; CHEN GONG ; SONG XUE</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN107118164A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2017</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>XIE SUQIONG</creatorcontrib><creatorcontrib>CHEN GONG</creatorcontrib><creatorcontrib>SONG XUE</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>XIE SUQIONG</au><au>CHEN GONG</au><au>SONG XUE</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Preparation method of 5-chloro-6-(chloromethyl)-2,4-(1H,3H)-pyrimidinedione</title><date>2017-09-01</date><risdate>2017</risdate><abstract>The patent provides a preparation method of 5-chloro-6-(chloromethyl)-2,4-(1H,3H)-pyrimidinedione. Orotic acid, which is used as a starting material, undergoes alpha-hydrogen chlorination; then, carboxyl is directly reduced to hydroxymethyl; and a chlorination replacement reaction is carried out. Through the three-step reactions, the target product is obtained. The preparation method of the invention is simple to operate, has stable process, has high yield, is low-cost, and is suitable for industrial production.
本专利提供种5-氯-6-氯甲基-2，4-(1H，3H)-嘧啶二酮的制备方法，以乳清酸为起始原料，通过α氢的氯代反应，再直接还原羧基为羟甲基，并进行氯化置换反应等三步反应，得到目标产物。本发明操作简单，工艺稳定，产率高，成本低，适合工业生产。</abstract><oa>free_for_read</oa></addata></record> |
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| title | Preparation method of 5-chloro-6-(chloromethyl)-2,4-(1H,3H)-pyrimidinedione |
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