Nanoparticles of eight-arm PEG (polyethylene glycol)-oleanolic acid drug carrier and preparation
The invention discloses a preparation method of nanoparticles of an eight-arm PEG (polyethylene glycol)-oleanolic acid drug carrier. The preparation method comprises steps as follows: eight-arm PEG and oleanolic acid are subjected to an esterification reaction, and a conjugate of eight-arm PEG-olean...
Gespeichert in:
Hauptverfasser: | , , , , |
---|---|
Format: | Patent |
Sprache: | chi ; eng |
Schlagworte: | |
Online-Zugang: | Volltext bestellen |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | |
---|---|
container_issue | |
container_start_page | |
container_title | |
container_volume | |
creator | MA YUNYUN HE JING LEI JIANDU WANG YINGSA ZHU PENGBO |
description | The invention discloses a preparation method of nanoparticles of an eight-arm PEG (polyethylene glycol)-oleanolic acid drug carrier. The preparation method comprises steps as follows: eight-arm PEG and oleanolic acid are subjected to an esterification reaction, and a conjugate of eight-arm PEG-oleanolic acid is obtained; 10-hydroxycamptothecine is wrapped with eight-arm PEG-oleanolic acid through self-assembly, and the nanoparticles are obtained. The nanoparticles have a double-layer structure, the outer layer is hydrophilic PEG, and the inner layer is hydrophobic oleanolic acid drug and 10-hydroxycamptothecine. The preparation method has the advantages that the drug loading capacity is greatly increased with the adoption of PEG; the water solubility and stability of oleanolic acid are increased, and the half-life period of oleanolic acid is prolonged; pH sensitive release of the drug in tumor cells can be realized; the toxic and side effects on normal tissue are reduced; the preparation process is simple and |
format | Patent |
fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_CN107115323A</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>CN107115323A</sourcerecordid><originalsourceid>FETCH-epo_espacenet_CN107115323A3</originalsourceid><addsrcrecordid>eNqNjDEOwjAMALswIOAPZoOhEiVCzKgqMFUM7MVK3DSSiSM3DP09HXgA0y13tyxeLUZJqDlYphGkBwp-yCXqGx7NDXZJeKI8TEyRwPNkhfelMM0ZBwtogwOnHw8WVQMpYHSQlOYn5iBxXSx65JE2P66K7bV51veSknQ0JrTzOHd1Wx3OVXUyR3Mx_zhfg0082g</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>Nanoparticles of eight-arm PEG (polyethylene glycol)-oleanolic acid drug carrier and preparation</title><source>esp@cenet</source><creator>MA YUNYUN ; HE JING ; LEI JIANDU ; WANG YINGSA ; ZHU PENGBO</creator><creatorcontrib>MA YUNYUN ; HE JING ; LEI JIANDU ; WANG YINGSA ; ZHU PENGBO</creatorcontrib><description>The invention discloses a preparation method of nanoparticles of an eight-arm PEG (polyethylene glycol)-oleanolic acid drug carrier. The preparation method comprises steps as follows: eight-arm PEG and oleanolic acid are subjected to an esterification reaction, and a conjugate of eight-arm PEG-oleanolic acid is obtained; 10-hydroxycamptothecine is wrapped with eight-arm PEG-oleanolic acid through self-assembly, and the nanoparticles are obtained. The nanoparticles have a double-layer structure, the outer layer is hydrophilic PEG, and the inner layer is hydrophobic oleanolic acid drug and 10-hydroxycamptothecine. The preparation method has the advantages that the drug loading capacity is greatly increased with the adoption of PEG; the water solubility and stability of oleanolic acid are increased, and the half-life period of oleanolic acid is prolonged; pH sensitive release of the drug in tumor cells can be realized; the toxic and side effects on normal tissue are reduced; the preparation process is simple and</description><language>chi ; eng</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2017</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20170901&DB=EPODOC&CC=CN&NR=107115323A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,309,782,887,25571,76555</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20170901&DB=EPODOC&CC=CN&NR=107115323A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>MA YUNYUN</creatorcontrib><creatorcontrib>HE JING</creatorcontrib><creatorcontrib>LEI JIANDU</creatorcontrib><creatorcontrib>WANG YINGSA</creatorcontrib><creatorcontrib>ZHU PENGBO</creatorcontrib><title>Nanoparticles of eight-arm PEG (polyethylene glycol)-oleanolic acid drug carrier and preparation</title><description>The invention discloses a preparation method of nanoparticles of an eight-arm PEG (polyethylene glycol)-oleanolic acid drug carrier. The preparation method comprises steps as follows: eight-arm PEG and oleanolic acid are subjected to an esterification reaction, and a conjugate of eight-arm PEG-oleanolic acid is obtained; 10-hydroxycamptothecine is wrapped with eight-arm PEG-oleanolic acid through self-assembly, and the nanoparticles are obtained. The nanoparticles have a double-layer structure, the outer layer is hydrophilic PEG, and the inner layer is hydrophobic oleanolic acid drug and 10-hydroxycamptothecine. The preparation method has the advantages that the drug loading capacity is greatly increased with the adoption of PEG; the water solubility and stability of oleanolic acid are increased, and the half-life period of oleanolic acid is prolonged; pH sensitive release of the drug in tumor cells can be realized; the toxic and side effects on normal tissue are reduced; the preparation process is simple and</description><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2017</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjDEOwjAMALswIOAPZoOhEiVCzKgqMFUM7MVK3DSSiSM3DP09HXgA0y13tyxeLUZJqDlYphGkBwp-yCXqGx7NDXZJeKI8TEyRwPNkhfelMM0ZBwtogwOnHw8WVQMpYHSQlOYn5iBxXSx65JE2P66K7bV51veSknQ0JrTzOHd1Wx3OVXUyR3Mx_zhfg0082g</recordid><startdate>20170901</startdate><enddate>20170901</enddate><creator>MA YUNYUN</creator><creator>HE JING</creator><creator>LEI JIANDU</creator><creator>WANG YINGSA</creator><creator>ZHU PENGBO</creator><scope>EVB</scope></search><sort><creationdate>20170901</creationdate><title>Nanoparticles of eight-arm PEG (polyethylene glycol)-oleanolic acid drug carrier and preparation</title><author>MA YUNYUN ; HE JING ; LEI JIANDU ; WANG YINGSA ; ZHU PENGBO</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN107115323A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2017</creationdate><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>MA YUNYUN</creatorcontrib><creatorcontrib>HE JING</creatorcontrib><creatorcontrib>LEI JIANDU</creatorcontrib><creatorcontrib>WANG YINGSA</creatorcontrib><creatorcontrib>ZHU PENGBO</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>MA YUNYUN</au><au>HE JING</au><au>LEI JIANDU</au><au>WANG YINGSA</au><au>ZHU PENGBO</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Nanoparticles of eight-arm PEG (polyethylene glycol)-oleanolic acid drug carrier and preparation</title><date>2017-09-01</date><risdate>2017</risdate><abstract>The invention discloses a preparation method of nanoparticles of an eight-arm PEG (polyethylene glycol)-oleanolic acid drug carrier. The preparation method comprises steps as follows: eight-arm PEG and oleanolic acid are subjected to an esterification reaction, and a conjugate of eight-arm PEG-oleanolic acid is obtained; 10-hydroxycamptothecine is wrapped with eight-arm PEG-oleanolic acid through self-assembly, and the nanoparticles are obtained. The nanoparticles have a double-layer structure, the outer layer is hydrophilic PEG, and the inner layer is hydrophobic oleanolic acid drug and 10-hydroxycamptothecine. The preparation method has the advantages that the drug loading capacity is greatly increased with the adoption of PEG; the water solubility and stability of oleanolic acid are increased, and the half-life period of oleanolic acid is prolonged; pH sensitive release of the drug in tumor cells can be realized; the toxic and side effects on normal tissue are reduced; the preparation process is simple and</abstract><oa>free_for_read</oa></addata></record> |
fulltext | fulltext_linktorsrc |
identifier | |
ispartof | |
issn | |
language | chi ; eng |
recordid | cdi_epo_espacenet_CN107115323A |
source | esp@cenet |
subjects | HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
title | Nanoparticles of eight-arm PEG (polyethylene glycol)-oleanolic acid drug carrier and preparation |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-05T19%3A17%3A46IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=MA%20YUNYUN&rft.date=2017-09-01&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3ECN107115323A%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |