Thymine derivatives and quinazoline-dione derivatives for the inhibition of hsp27
The present invention relates to novel HSP27 inhibitors, in particular thymine derivatives according to general formula (VI), (VII) or (VII) and phenothiazine derivatives according to formula (V), and to their use as drugs for the selective inhibition of the heat shock protein HSP27 (HSPB1), in part...
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| creator | HEINRICH JORGRISTIAN DONAKONDA SAINITIN SCHROEDER MICHAEL PROF DR HAUPT JOACHIM LENNIG PETRA DR ZHANG YIXIN |
| description | The present invention relates to novel HSP27 inhibitors, in particular thymine derivatives according to general formula (VI), (VII) or (VII) and phenothiazine derivatives according to formula (V), and to their use as drugs for the selective inhibition of the heat shock protein HSP27 (HSPB1), in particular for use in the treatment of carcinomas or cystic fibrosis, said inhibitors having a particularly advantageous activity in the lower micromolar or sub-micromolar active ingredient concentration range with respect to HSP27.
本发明涉及新的HSP27抑制剂，尤其是根据通式(VI)、(VII)或(VII)的胸腺嘧啶衍生物和根据通式(V)的吩噻嗪衍生物，以及它们作为热休克蛋白HSP27(HSPB1)选择性抑制药物的应用，特别是应用于癌症或囊性纤维病的治疗，其中所述抑制剂相对于HSP27在低微摩尔和亚微摩尔的药物浓度范围内具有特别有利的活性。 |
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本发明涉及新的HSP27抑制剂，尤其是根据通式(VI)、(VII)或(VII)的胸腺嘧啶衍生物和根据通式(V)的吩噻嗪衍生物，以及它们作为热休克蛋白HSP27(HSPB1)选择性抑制药物的应用，特别是应用于癌症或囊性纤维病的治疗，其中所述抑制剂相对于HSP27在低微摩尔和亚微摩尔的药物浓度范围内具有特别有利的活性。</description><language>chi ; eng</language><subject>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM ; CHEMISTRY ; DERIVATIVES THEREOF ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; NUCLEIC ACIDS ; NUCLEOSIDES ; NUCLEOTIDES ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SUGARS</subject><creationdate>2017</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20170818&DB=EPODOC&CC=CN&NR=107074791A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25555,76308</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20170818&DB=EPODOC&CC=CN&NR=107074791A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>HEINRICH JORGRISTIAN</creatorcontrib><creatorcontrib>DONAKONDA SAINITIN</creatorcontrib><creatorcontrib>SCHROEDER MICHAEL PROF DR</creatorcontrib><creatorcontrib>HAUPT JOACHIM</creatorcontrib><creatorcontrib>LENNIG PETRA DR</creatorcontrib><creatorcontrib>ZHANG YIXIN</creatorcontrib><title>Thymine derivatives and quinazoline-dione derivatives for the inhibition of hsp27</title><description>The present invention relates to novel HSP27 inhibitors, in particular thymine derivatives according to general formula (VI), (VII) or (VII) and phenothiazine derivatives according to formula (V), and to their use as drugs for the selective inhibition of the heat shock protein HSP27 (HSPB1), in particular for use in the treatment of carcinomas or cystic fibrosis, said inhibitors having a particularly advantageous activity in the lower micromolar or sub-micromolar active ingredient concentration range with respect to HSP27.
本发明涉及新的HSP27抑制剂，尤其是根据通式(VI)、(VII)或(VII)的胸腺嘧啶衍生物和根据通式(V)的吩噻嗪衍生物，以及它们作为热休克蛋白HSP27(HSPB1)选择性抑制药物的应用，特别是应用于癌症或囊性纤维病的治疗，其中所述抑制剂相对于HSP27在低微摩尔和亚微摩尔的药物浓度范围内具有特别有利的活性。</description><subject>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM</subject><subject>CHEMISTRY</subject><subject>DERIVATIVES THEREOF</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>NUCLEIC ACIDS</subject><subject>NUCLEOSIDES</subject><subject>NUCLEOTIDES</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SUGARS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2017</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZAgMyajMzcxLVUhJLcosSyzJLEstVkjMS1EoLM3MS6zKzwHK6aZk5qOpSMsvUijJSFXIzMvITMosAcor5KcpZBQXGJnzMLCmJeYUp_JCaW4GRTfXEGcP3dSC_PjU4oLE5NS81JJ4Zz9DA3MDcxNzS0NHY2LUAAAM2Dfm</recordid><startdate>20170818</startdate><enddate>20170818</enddate><creator>HEINRICH JORGRISTIAN</creator><creator>DONAKONDA SAINITIN</creator><creator>SCHROEDER MICHAEL PROF DR</creator><creator>HAUPT JOACHIM</creator><creator>LENNIG PETRA DR</creator><creator>ZHANG YIXIN</creator><scope>EVB</scope></search><sort><creationdate>20170818</creationdate><title>Thymine derivatives and quinazoline-dione derivatives for the inhibition of hsp27</title><author>HEINRICH JORGRISTIAN ; DONAKONDA SAINITIN ; SCHROEDER MICHAEL PROF DR ; HAUPT JOACHIM ; LENNIG PETRA DR ; ZHANG YIXIN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN107074791A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2017</creationdate><topic>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM</topic><topic>CHEMISTRY</topic><topic>DERIVATIVES THEREOF</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>NUCLEIC ACIDS</topic><topic>NUCLEOSIDES</topic><topic>NUCLEOTIDES</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SUGARS</topic><toplevel>online_resources</toplevel><creatorcontrib>HEINRICH JORGRISTIAN</creatorcontrib><creatorcontrib>DONAKONDA SAINITIN</creatorcontrib><creatorcontrib>SCHROEDER MICHAEL PROF DR</creatorcontrib><creatorcontrib>HAUPT JOACHIM</creatorcontrib><creatorcontrib>LENNIG PETRA DR</creatorcontrib><creatorcontrib>ZHANG YIXIN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>HEINRICH JORGRISTIAN</au><au>DONAKONDA SAINITIN</au><au>SCHROEDER MICHAEL PROF DR</au><au>HAUPT JOACHIM</au><au>LENNIG PETRA DR</au><au>ZHANG YIXIN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Thymine derivatives and quinazoline-dione derivatives for the inhibition of hsp27</title><date>2017-08-18</date><risdate>2017</risdate><abstract>The present invention relates to novel HSP27 inhibitors, in particular thymine derivatives according to general formula (VI), (VII) or (VII) and phenothiazine derivatives according to formula (V), and to their use as drugs for the selective inhibition of the heat shock protein HSP27 (HSPB1), in particular for use in the treatment of carcinomas or cystic fibrosis, said inhibitors having a particularly advantageous activity in the lower micromolar or sub-micromolar active ingredient concentration range with respect to HSP27.
本发明涉及新的HSP27抑制剂，尤其是根据通式(VI)、(VII)或(VII)的胸腺嘧啶衍生物和根据通式(V)的吩噻嗪衍生物，以及它们作为热休克蛋白HSP27(HSPB1)选择性抑制药物的应用，特别是应用于癌症或囊性纤维病的治疗，其中所述抑制剂相对于HSP27在低微摩尔和亚微摩尔的药物浓度范围内具有特别有利的活性。</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY DERIVATIVES THEREOF HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SUGARS |
| title | Thymine derivatives and quinazoline-dione derivatives for the inhibition of hsp27 |
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