Method for purifying anidulafungin precursor compound

Method for purifying anidulafungin precursor compound

The invention discloses a method for purifying an anidulafungin precursor compound. The method comprises the process steps of flocculation, acidification, filter pressing, nanofiltration, purification, salting-out and recrystallization. The method mainly comprises the following steps of adding kiese...

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Hauptverfasser: MIN HAIXIA, LIU QING, XUN SHUNYI, ZHU HAI, ZHANG ZHIHUI, ZHANG XIAORONG
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Sprache:chi ; eng
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CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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creator MIN HAIXIA
LIU QING
XUN SHUNYI
ZHU HAI
ZHANG ZHIHUI
ZHANG XIAORONG
description The invention discloses a method for purifying an anidulafungin precursor compound. The method comprises the process steps of flocculation, acidification, filter pressing, nanofiltration, purification, salting-out and recrystallization. The method mainly comprises the following steps of adding kieselguhr to a fermentation conversion liquid, stirring, flocculating, adjusting the pH by using hydrochloric acid, carrying out plate-frame filter pressing, collecting filter pressing filtrate, and carrying out low-temperature nanofiltration concentration on the filter pressing filtrate; adding methyl tertiary butyl ether or petroleum ether to a nanofiltration concentration solution for stirring and extracting, removing an organic phase of an impurity, and adding methanol or ethanol or a little of sodium chloride in a water phase for crystallization; and repeating a crystallization process and carrying out recrystallization to obtain the anidulafungin precursor compound. The method has the advantages that extraction i
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The method comprises the process steps of flocculation, acidification, filter pressing, nanofiltration, purification, salting-out and recrystallization. The method mainly comprises the following steps of adding kieselguhr to a fermentation conversion liquid, stirring, flocculating, adjusting the pH by using hydrochloric acid, carrying out plate-frame filter pressing, collecting filter pressing filtrate, and carrying out low-temperature nanofiltration concentration on the filter pressing filtrate; adding methyl tertiary butyl ether or petroleum ether to a nanofiltration concentration solution for stirring and extracting, removing an organic phase of an impurity, and adding methanol or ethanol or a little of sodium chloride in a water phase for crystallization; and repeating a crystallization process and carrying out recrystallization to obtain the anidulafungin precursor compound. 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subjects CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
title Method for purifying anidulafungin precursor compound
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