Perylenequinones and preparation method and application thereof
The invention discloses perylenequinones and preparation method and application thereof, and relates to the technical field of medicines. Specifically, the new perylenequinones called as Hypocrellin E is obtained by separating from a stroma of Shiraia bambusicola Henn. through a certain preparation...
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| creator | CHEN WEIKANG ZHENG YANGBIN JI TENGFEI KUANG PEILIN LIANG YAN ZHONG RUIJIAN YUAN MINGMING ZHOU GUOPING |
| description | The invention discloses perylenequinones and preparation method and application thereof, and relates to the technical field of medicines. Specifically, the new perylenequinones called as Hypocrellin E is obtained by separating from a stroma of Shiraia bambusicola Henn. through a certain preparation step. Through detection by the superconducting nuclear magnetic resonance spectrum, mass spectrum and the like, the molecular formula of the Hypocrellin E is determined as C3OH22O9, the molecular weight is 526, and the chemical structural formula is a formula (I). The invention discloses the physicochemical property and the optical activity of the Hypocrellin E, and performs the in vitro activity screening by use of an MTT method; a result shows that the Hypocrellin E has obvious inhibition effects on human gastric carcinoma cells, human hepatoma carcinoma cells, human colon carcinoma cells, human ovarian carcinoma cells and human lung carcinoma cells; the Hypocrellin E can be used as a lead compound for researchin |
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Specifically, the new perylenequinones called as Hypocrellin E is obtained by separating from a stroma of Shiraia bambusicola Henn. through a certain preparation step. Through detection by the superconducting nuclear magnetic resonance spectrum, mass spectrum and the like, the molecular formula of the Hypocrellin E is determined as C3OH22O9, the molecular weight is 526, and the chemical structural formula is a formula (I). The invention discloses the physicochemical property and the optical activity of the Hypocrellin E, and performs the in vitro activity screening by use of an MTT method; a result shows that the Hypocrellin E has obvious inhibition effects on human gastric carcinoma cells, human hepatoma carcinoma cells, human colon carcinoma cells, human ovarian carcinoma cells and human lung carcinoma cells; the Hypocrellin E can be used as a lead compound for researchin</description><language>chi ; eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2017</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20170531&DB=EPODOC&CC=CN&NR=106749158A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76516</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20170531&DB=EPODOC&CC=CN&NR=106749158A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>CHEN WEIKANG</creatorcontrib><creatorcontrib>ZHENG YANGBIN</creatorcontrib><creatorcontrib>JI TENGFEI</creatorcontrib><creatorcontrib>KUANG PEILIN</creatorcontrib><creatorcontrib>LIANG YAN</creatorcontrib><creatorcontrib>ZHONG RUIJIAN</creatorcontrib><creatorcontrib>YUAN MINGMING</creatorcontrib><creatorcontrib>ZHOU GUOPING</creatorcontrib><title>Perylenequinones and preparation method and application thereof</title><description>The invention discloses perylenequinones and preparation method and application thereof, and relates to the technical field of medicines. 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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Perylenequinones and preparation method and application thereof |
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