Ternary conjugates for antineoplastic drugs, compound and application
The invention relates to a target transfer system for an antineoplastic lyophobic drug and mainly relates to E selectin polypeptide ligand-polyethylene glycol-antineoplastic drug conjugates containing disulfide bonds and connected with different link bridges, including compounding of conjugates, ant...
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| creator | GUO NA TENG YUOU HAO TIANTIAN WANG DONG SHANG XIUZHUAN LIU HUAN ZHANG TIANLE YU PENG |
| description | The invention relates to a target transfer system for an antineoplastic lyophobic drug and mainly relates to E selectin polypeptide ligand-polyethylene glycol-antineoplastic drug conjugates containing disulfide bonds and connected with different link bridges, including compounding of conjugates, antineoplastic activity evaluation, particle size and morphological characteristics of nanometer particles formed by self-polymerization of the conjugates in aqueous solution and release conditions of antineoplastic drugs under different conditions. The conjugates can actively target to tumor locus blood vessels through E selectin polypeptide ligands and also can self-polymerize into nanometer particles in an aqueous solution so as to be passively targeted to the tumor locus through EPR effect. A result shows that the compounds have obvious antineoplastic activity and low toxicity to normal cells; the compounds can restrain the adhesion of tumor cells and vascular endothelial cells, so that the compounds have the pote |
| format | Patent |
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| title | Ternary conjugates for antineoplastic drugs, compound and application |
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