6-APA (6-amino-penicillanic acid) and preparation method thereof
The invention provides a preparation method of 6-APA (6-amino-penicillanic acid). 6-APA is prepared from a potassium carbonate reversed-extraction liquid of benzylpenicillin potassium directly, a molecular formula of 6-APA is C8H12N2O3S, and the molecular weight is 216.26. With the adoption of the p...
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| creator | YAN LIBEI YAN LIBING YANG SHENGJIN ZHANG MINGHE |
| description | The invention provides a preparation method of 6-APA (6-amino-penicillanic acid). 6-APA is prepared from a potassium carbonate reversed-extraction liquid of benzylpenicillin potassium directly, a molecular formula of 6-APA is C8H12N2O3S, and the molecular weight is 216.26. With the adoption of the process, a crystallization step can be omitted, and crystallization yield loss is avoided; extracting and washing processes of a penicillin solvent are optimized in a technical process; with the adoption of the advanced preparation process, the preparation method is higher in yield and lower in cost.
种6-氨基青霉烷酸（6-APA）的制备方法，直接采用青霉素钾的碳酸钾反萃取液制取。所述6-APA的分子式为C8H12N2O3S，分子量为216.26。采用此种工艺可以省去结晶步骤，避免结晶收率损失。本发明的工艺过程中，对青霉素溶媒萃取、水洗工艺进行了优化。本发明采用了先进制备工艺，有较高收率和较低成本。 |
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种6-氨基青霉烷酸（6-APA）的制备方法，直接采用青霉素钾的碳酸钾反萃取液制取。所述6-APA的分子式为C8H12N2O3S，分子量为216.26。采用此种工艺可以省去结晶步骤，避免结晶收率损失。本发明的工艺过程中，对青霉素溶媒萃取、水洗工艺进行了优化。本发明采用了先进制备工艺，有较高收率和较低成本。</description><language>chi ; eng</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; ENZYMOLOGY ; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; MICROBIOLOGY ; MUTATION OR GENETIC ENGINEERING ; ORGANIC CHEMISTRY ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2016</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20161109&DB=EPODOC&CC=CN&NR=106086151A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20161109&DB=EPODOC&CC=CN&NR=106086151A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>YAN LIBEI</creatorcontrib><creatorcontrib>YAN LIBING</creatorcontrib><creatorcontrib>YANG SHENGJIN</creatorcontrib><creatorcontrib>ZHANG MINGHE</creatorcontrib><title>6-APA (6-amino-penicillanic acid) and preparation method thereof</title><description>The invention provides a preparation method of 6-APA (6-amino-penicillanic acid). 6-APA is prepared from a potassium carbonate reversed-extraction liquid of benzylpenicillin potassium directly, a molecular formula of 6-APA is C8H12N2O3S, and the molecular weight is 216.26. With the adoption of the process, a crystallization step can be omitted, and crystallization yield loss is avoided; extracting and washing processes of a penicillin solvent are optimized in a technical process; with the adoption of the advanced preparation process, the preparation method is higher in yield and lower in cost.
种6-氨基青霉烷酸（6-APA）的制备方法，直接采用青霉素钾的碳酸钾反萃取液制取。所述6-APA的分子式为C8H12N2O3S，分子量为216.26。采用此种工艺可以省去结晶步骤，避免结晶收率损失。本发明的工艺过程中，对青霉素溶媒萃取、水洗工艺进行了优化。本发明采用了先进制备工艺，有较高收率和较低成本。</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>ENZYMOLOGY</subject><subject>FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>ORGANIC CHEMISTRY</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2016</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZHAw03UMcFTQMNNNzM3My9ctSM3LTM7MyUkEUgqJyZkpmgqJeSkKBUWpBYlFiSWZ-XkKuaklGfkpCiUZqUWp-Wk8DKxpiTnFqbxQmptB0c01xNlDN7UgPz61uCAxOTUvtSTe2c_QwMzAwszQ1NDRmBg1AO8YL8s</recordid><startdate>20161109</startdate><enddate>20161109</enddate><creator>YAN LIBEI</creator><creator>YAN LIBING</creator><creator>YANG SHENGJIN</creator><creator>ZHANG MINGHE</creator><scope>EVB</scope></search><sort><creationdate>20161109</creationdate><title>6-APA (6-amino-penicillanic acid) and preparation method thereof</title><author>YAN LIBEI ; YAN LIBING ; YANG SHENGJIN ; ZHANG MINGHE</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN106086151A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2016</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>ENZYMOLOGY</topic><topic>FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>ORGANIC CHEMISTRY</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>YAN LIBEI</creatorcontrib><creatorcontrib>YAN LIBING</creatorcontrib><creatorcontrib>YANG SHENGJIN</creatorcontrib><creatorcontrib>ZHANG MINGHE</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>YAN LIBEI</au><au>YAN LIBING</au><au>YANG SHENGJIN</au><au>ZHANG MINGHE</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>6-APA (6-amino-penicillanic acid) and preparation method thereof</title><date>2016-11-09</date><risdate>2016</risdate><abstract>The invention provides a preparation method of 6-APA (6-amino-penicillanic acid). 6-APA is prepared from a potassium carbonate reversed-extraction liquid of benzylpenicillin potassium directly, a molecular formula of 6-APA is C8H12N2O3S, and the molecular weight is 216.26. With the adoption of the process, a crystallization step can be omitted, and crystallization yield loss is avoided; extracting and washing processes of a penicillin solvent are optimized in a technical process; with the adoption of the advanced preparation process, the preparation method is higher in yield and lower in cost.
种6-氨基青霉烷酸（6-APA）的制备方法，直接采用青霉素钾的碳酸钾反萃取液制取。所述6-APA的分子式为C8H12N2O3S，分子量为216.26。采用此种工艺可以省去结晶步骤，避免结晶收率损失。本发明的工艺过程中，对青霉素溶媒萃取、水洗工艺进行了优化。本发明采用了先进制备工艺，有较高收率和较低成本。</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HETEROCYCLIC COMPOUNDS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY SPIRITS VINEGAR WINE |
| title | 6-APA (6-amino-penicillanic acid) and preparation method thereof |
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