Withanolides type compound and use thereof

The invention relates to a compound and use thereof, particularly discloses a withanolides type compound and use thereof, and belongs to the technical field of chemistry. The invention discloses two novel withanolides compounds and anti-tumor use thereof, and belongs to the field of natural pharmaceutical chemistry. Compounds I and II are reported for the first time, and can both be separated and purified from dry aboveground parts of physalis angulata L.. In-vitro activity tests show that the compounds I and II can be used for remarkably suppressing growth of human osteosarcoma cells and human hepatoma carcinoma cells and can be researched and developed into a medicament for treating human osteosarcoma and human hepatoma carcinoma. 本发明涉及种化合物及其用途，尤其是withanolides型化合物及其用途，属于化学技术领域。本发明公开了两个新的睡茄内酯类化合物及其抗肿瘤用途，属于天然药物化学领域。化合物Ⅰ和Ⅱ均为首次报道，均可从苦蘵干燥的地上部分分离纯化得到。体外活性测试证明化合物Ⅰ和Ⅱ可显著的抑制人骨肉瘤细胞、人肝癌细胞的生长，可研究开发成治疗人骨肉瘤、肝癌的药物。