Substituted 4,5,6,7-tetrahydropyrazolo[1,5-A]pyrazine derivatives as casein kinase 1 D/E inhibitors

Substituted 4,5,6,7-tetrahydropyrazolo[1,5-A]pyrazine derivatives as casein kinase 1 D/E inhibitors

The invention provides compounds of Formula (I): and pharmaceutically acceptable salts thereof. The compounds of Formula (I) inhibit protein kinase activity thereby making them useful as anticancer agents. 本发明披露了式(I)化合物及其药用盐。所述式(I)化合物抑制蛋白激酶活性，由此适合用作抗癌剂。...

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Hauptverfasser: RAO METTU MALLIKARJUNA, RACHAMREDDY CHANDRASEKHAR REDDY, JANAKIRAMAN SAKTHI KUMARAN, NAGALAKSHMI PULICHARLA, WITTMAN MARK D, Liu Peiying, VELAPARTHI UPENDER, SISTLA RAMESH, NAIR JALATHI SURENDRAN, BORA RAJESH ONKARDAS, KARUPPIAH ARUL MOZHI SELVAN SUBBIAH, DARNE CHETAN PADMAKAR, DASGUPTA BIRESHWAR, KUMARAVEL SELVAKUMAR, MULLICK DIBAKAR, ARAUJO ERIKA M V, REDDY BANDREDDY SUBBA, MAHESHWARAPPA SHILPA HOLEHATTI, PEARCE BRADLEY C
Format: Patent
Sprache:chi ; eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:The invention provides compounds of Formula (I): and pharmaceutically acceptable salts thereof. The compounds of Formula (I) inhibit protein kinase activity thereby making them useful as anticancer agents. 本发明披露了式(I)化合物及其药用盐。所述式(I)化合物抑制蛋白激酶活性，由此适合用作抗癌剂。