Method for synthesizing kukoamine A and analogue thereof
The invention relates to the technical field of medicines, and relates to a method for synthesizing a natural product kukoamine A and analogue thereof. The method comprises the following steps: (1) performing a nucleophilic reaction on hydroxyl, halogen or C1-C10 alkoxy or C1-C10 alkyl substituted o...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , |
|---|---|
| Format: | Patent |
| Sprache: | chi ; eng |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | Tian Ye Zhang Hui Liu Jianyu Liu Yifeng Xu Yongnan Zhang Hefeng Liu Dan Zhan Yong Zhao Qingchun Chi Mingshuang Ao Jiwei |
| description | The invention relates to the technical field of medicines, and relates to a method for synthesizing a natural product kukoamine A and analogue thereof. The method comprises the following steps: (1) performing a nucleophilic reaction on hydroxyl, halogen or C1-C10 alkoxy or C1-C10 alkyl substituted or unsubstituted benzaldehyde and malonic acid to obtain a compound 1; (2) reacting the compound 1 in the step (1) with N-hydroxy succinimide to obtain a compound 2; (3) reacting the compound 2 with spermine to obtain a compound 3; and (4) reacting the compound 3 with hydrogen to reduce carbon-carbon double bond, and purifying. The preparation method is simple, and provides a compound base to pharmacological activity research of compounds with similar structures.
本发明涉及医药技术领域，涉及天然产物地骨皮甲素及其类似物的合成方法。该方法包括：1)由羟基、卤素或C1-C10烷氧基或C1-C10烷基取代或未取代的苯甲醛与丙二酸进行亲核反应得化合物1；2)步骤1)所得化合物1和N-羟基琥珀酰亚胺反应，得化合物2；3)化合物2和精胺反应，得化合物3；4）化合物3用氢气反应以还原碳-碳双键，纯化即得。本发明制备方法简单，为类似结构化合物的药物活性研究提供了化合物基础。 |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_CN105906525A</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>CN105906525A</sourcerecordid><originalsourceid>FETCH-epo_espacenet_CN105906525A3</originalsourceid><addsrcrecordid>eNrjZLDwTS3JyE9RSMsvUiiuzCvJSC3OrMrMS1fILs3OT8zNzEtVcFRIzEsB4sSc_PTSVAWgkqLU_DQeBta0xJziVF4ozc2g6OYa4uyhm1qQH59aXJCYnJqXWhLv7GdoYGppYGZqZOpoTIwaAAwaLkk</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>Method for synthesizing kukoamine A and analogue thereof</title><source>esp@cenet</source><creator>Tian Ye ; Zhang Hui ; Liu Jianyu ; Liu Yifeng ; Xu Yongnan ; Zhang Hefeng ; Liu Dan ; Zhan Yong ; Zhao Qingchun ; Chi Mingshuang ; Ao Jiwei</creator><creatorcontrib>Tian Ye ; Zhang Hui ; Liu Jianyu ; Liu Yifeng ; Xu Yongnan ; Zhang Hefeng ; Liu Dan ; Zhan Yong ; Zhao Qingchun ; Chi Mingshuang ; Ao Jiwei</creatorcontrib><description>The invention relates to the technical field of medicines, and relates to a method for synthesizing a natural product kukoamine A and analogue thereof. The method comprises the following steps: (1) performing a nucleophilic reaction on hydroxyl, halogen or C1-C10 alkoxy or C1-C10 alkyl substituted or unsubstituted benzaldehyde and malonic acid to obtain a compound 1; (2) reacting the compound 1 in the step (1) with N-hydroxy succinimide to obtain a compound 2; (3) reacting the compound 2 with spermine to obtain a compound 3; and (4) reacting the compound 3 with hydrogen to reduce carbon-carbon double bond, and purifying. The preparation method is simple, and provides a compound base to pharmacological activity research of compounds with similar structures.
本发明涉及医药技术领域，涉及天然产物地骨皮甲素及其类似物的合成方法。该方法包括：1)由羟基、卤素或C1-C10烷氧基或C1-C10烷基取代或未取代的苯甲醛与丙二酸进行亲核反应得化合物1；2)步骤1)所得化合物1和N-羟基琥珀酰亚胺反应，得化合物2；3)化合物2和精胺反应，得化合物3；4）化合物3用氢气反应以还原碳-碳双键，纯化即得。本发明制备方法简单，为类似结构化合物的药物活性研究提供了化合物基础。</description><language>chi ; eng</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>2016</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20160831&DB=EPODOC&CC=CN&NR=105906525A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20160831&DB=EPODOC&CC=CN&NR=105906525A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Tian Ye</creatorcontrib><creatorcontrib>Zhang Hui</creatorcontrib><creatorcontrib>Liu Jianyu</creatorcontrib><creatorcontrib>Liu Yifeng</creatorcontrib><creatorcontrib>Xu Yongnan</creatorcontrib><creatorcontrib>Zhang Hefeng</creatorcontrib><creatorcontrib>Liu Dan</creatorcontrib><creatorcontrib>Zhan Yong</creatorcontrib><creatorcontrib>Zhao Qingchun</creatorcontrib><creatorcontrib>Chi Mingshuang</creatorcontrib><creatorcontrib>Ao Jiwei</creatorcontrib><title>Method for synthesizing kukoamine A and analogue thereof</title><description>The invention relates to the technical field of medicines, and relates to a method for synthesizing a natural product kukoamine A and analogue thereof. The method comprises the following steps: (1) performing a nucleophilic reaction on hydroxyl, halogen or C1-C10 alkoxy or C1-C10 alkyl substituted or unsubstituted benzaldehyde and malonic acid to obtain a compound 1; (2) reacting the compound 1 in the step (1) with N-hydroxy succinimide to obtain a compound 2; (3) reacting the compound 2 with spermine to obtain a compound 3; and (4) reacting the compound 3 with hydrogen to reduce carbon-carbon double bond, and purifying. The preparation method is simple, and provides a compound base to pharmacological activity research of compounds with similar structures.
本发明涉及医药技术领域，涉及天然产物地骨皮甲素及其类似物的合成方法。该方法包括：1)由羟基、卤素或C1-C10烷氧基或C1-C10烷基取代或未取代的苯甲醛与丙二酸进行亲核反应得化合物1；2)步骤1)所得化合物1和N-羟基琥珀酰亚胺反应，得化合物2；3)化合物2和精胺反应，得化合物3；4）化合物3用氢气反应以还原碳-碳双键，纯化即得。本发明制备方法简单，为类似结构化合物的药物活性研究提供了化合物基础。</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2016</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLDwTS3JyE9RSMsvUiiuzCvJSC3OrMrMS1fILs3OT8zNzEtVcFRIzEsB4sSc_PTSVAWgkqLU_DQeBta0xJziVF4ozc2g6OYa4uyhm1qQH59aXJCYnJqXWhLv7GdoYGppYGZqZOpoTIwaAAwaLkk</recordid><startdate>20160831</startdate><enddate>20160831</enddate><creator>Tian Ye</creator><creator>Zhang Hui</creator><creator>Liu Jianyu</creator><creator>Liu Yifeng</creator><creator>Xu Yongnan</creator><creator>Zhang Hefeng</creator><creator>Liu Dan</creator><creator>Zhan Yong</creator><creator>Zhao Qingchun</creator><creator>Chi Mingshuang</creator><creator>Ao Jiwei</creator><scope>EVB</scope></search><sort><creationdate>20160831</creationdate><title>Method for synthesizing kukoamine A and analogue thereof</title><author>Tian Ye ; Zhang Hui ; Liu Jianyu ; Liu Yifeng ; Xu Yongnan ; Zhang Hefeng ; Liu Dan ; Zhan Yong ; Zhao Qingchun ; Chi Mingshuang ; Ao Jiwei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN105906525A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2016</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>Tian Ye</creatorcontrib><creatorcontrib>Zhang Hui</creatorcontrib><creatorcontrib>Liu Jianyu</creatorcontrib><creatorcontrib>Liu Yifeng</creatorcontrib><creatorcontrib>Xu Yongnan</creatorcontrib><creatorcontrib>Zhang Hefeng</creatorcontrib><creatorcontrib>Liu Dan</creatorcontrib><creatorcontrib>Zhan Yong</creatorcontrib><creatorcontrib>Zhao Qingchun</creatorcontrib><creatorcontrib>Chi Mingshuang</creatorcontrib><creatorcontrib>Ao Jiwei</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Tian Ye</au><au>Zhang Hui</au><au>Liu Jianyu</au><au>Liu Yifeng</au><au>Xu Yongnan</au><au>Zhang Hefeng</au><au>Liu Dan</au><au>Zhan Yong</au><au>Zhao Qingchun</au><au>Chi Mingshuang</au><au>Ao Jiwei</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Method for synthesizing kukoamine A and analogue thereof</title><date>2016-08-31</date><risdate>2016</risdate><abstract>The invention relates to the technical field of medicines, and relates to a method for synthesizing a natural product kukoamine A and analogue thereof. The method comprises the following steps: (1) performing a nucleophilic reaction on hydroxyl, halogen or C1-C10 alkoxy or C1-C10 alkyl substituted or unsubstituted benzaldehyde and malonic acid to obtain a compound 1; (2) reacting the compound 1 in the step (1) with N-hydroxy succinimide to obtain a compound 2; (3) reacting the compound 2 with spermine to obtain a compound 3; and (4) reacting the compound 3 with hydrogen to reduce carbon-carbon double bond, and purifying. The preparation method is simple, and provides a compound base to pharmacological activity research of compounds with similar structures.
本发明涉及医药技术领域，涉及天然产物地骨皮甲素及其类似物的合成方法。该方法包括：1)由羟基、卤素或C1-C10烷氧基或C1-C10烷基取代或未取代的苯甲醛与丙二酸进行亲核反应得化合物1；2)步骤1)所得化合物1和N-羟基琥珀酰亚胺反应，得化合物2；3)化合物2和精胺反应，得化合物3；4）化合物3用氢气反应以还原碳-碳双键，纯化即得。本发明制备方法简单，为类似结构化合物的药物活性研究提供了化合物基础。</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | chi ; eng |
| recordid | cdi_epo_espacenet_CN105906525A |
| source | esp@cenet |
| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY |
| title | Method for synthesizing kukoamine A and analogue thereof |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-26T05%3A09%3A23IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=Tian%20Ye&rft.date=2016-08-31&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3ECN105906525A%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |