A fermentation process

A method for altering the metabolite profile of a fermentation, by increasing flux through acetolactate. The method comprises increasing production of one or more products derived from acetolactate. Further provided is a method for increasing the production of 2,3-butandiol by microbial fermentation of gaseous substrates, the method comprising providing a compound which inhibits one or more enzymes which convert acetolactate to branched chain amino acids to the fermentation. The present invention further provides methods for increasing the production of 2,3-butandiol relative to other fermentation products such as ethanol and acetic acid. 本发明提供了通过增加通过乙酰乳酸的通量用于改变发酵的代谢产物谱的方法。该方法包括增加来源于乙酰乳酸的一种或多种产物的生产。本发明还提供的是通过气态底物的微生物发酵用于增加2,3?丁二醇的生产的方法，该方法包括给发酵提供化合物，所述化合物抑制将乙酰乳酸转化成支链氨基酸的一种或多种酶。本发明还提供了用于增加相对于其他发酵产物例如乙醇和乙酸的2,3?丁二醇生产的方法。