Ferulic acid derivatives, preparation and application of ferulic acid derivatives
The invention provides ferulic acid derivatives adopting a structure shown in formula I or formula II. Starting from the mechanism of various mechanisms causing brain injury after cerebral stroke and the action of ferulic acid in treatment of the cerebral stroke, alkane is taken as a joint arm, ADT-...
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| creator | JIA JIA SUN YINXING LI YUYAO CHENG JIAN AO GUIZHEN |
| description | The invention provides ferulic acid derivatives adopting a structure shown in formula I or formula II. Starting from the mechanism of various mechanisms causing brain injury after cerebral stroke and the action of ferulic acid in treatment of the cerebral stroke, alkane is taken as a joint arm, ADT-OH (5-(4-hydroxyphenyl)-3H-1,2-dithiole-3-thione) and ferulic acid are connected through ether linkage and ester linkage, and the ferulic acid derivatives are obtained. The invention further provides the application of the ferulic acid derivatives in preparation of drugs for preventing and/or treating cerebral stroke diseases.
本发明提供了种阿魏酸衍生物，具有式I或式II所示的结构，本发明从脑卒中后多种机制导致脑损伤的机理和阿魏酸在治疗脑中风中的作用出发，以烷烃为连接臂，将5-对羟基苯基-3H-1,2-二硫杂环戊烯-3-硫酮(ADT-OH)与阿魏酸通过醚键、酯键相连，得到阿魏酸衍生物。因而，本发明还提供了该阿魏酸衍生物在制备预防和/或治疗脑中风类疾病药物中的应用。 |
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本发明提供了种阿魏酸衍生物，具有式I或式II所示的结构，本发明从脑卒中后多种机制导致脑损伤的机理和阿魏酸在治疗脑中风中的作用出发，以烷烃为连接臂，将5-对羟基苯基-3H-1,2-二硫杂环戊烯-3-硫酮(ADT-OH)与阿魏酸通过醚键、酯键相连，得到阿魏酸衍生物。因而，本发明还提供了该阿魏酸衍生物在制备预防和/或治疗脑中风类疾病药物中的应用。</description><language>chi ; eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2016</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20160622&DB=EPODOC&CC=CN&NR=105693689A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20160622&DB=EPODOC&CC=CN&NR=105693689A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>JIA JIA</creatorcontrib><creatorcontrib>SUN YINXING</creatorcontrib><creatorcontrib>LI YUYAO</creatorcontrib><creatorcontrib>CHENG JIAN</creatorcontrib><creatorcontrib>AO GUIZHEN</creatorcontrib><title>Ferulic acid derivatives, preparation and application of ferulic acid derivatives</title><description>The invention provides ferulic acid derivatives adopting a structure shown in formula I or formula II. Starting from the mechanism of various mechanisms causing brain injury after cerebral stroke and the action of ferulic acid in treatment of the cerebral stroke, alkane is taken as a joint arm, ADT-OH (5-(4-hydroxyphenyl)-3H-1,2-dithiole-3-thione) and ferulic acid are connected through ether linkage and ester linkage, and the ferulic acid derivatives are obtained. The invention further provides the application of the ferulic acid derivatives in preparation of drugs for preventing and/or treating cerebral stroke diseases.
本发明提供了种阿魏酸衍生物，具有式I或式II所示的结构，本发明从脑卒中后多种机制导致脑损伤的机理和阿魏酸在治疗脑中风中的作用出发，以烷烃为连接臂，将5-对羟基苯基-3H-1,2-二硫杂环戊烯-3-硫酮(ADT-OH)与阿魏酸通过醚键、酯键相连，得到阿魏酸衍生物。因而，本发明还提供了该阿魏酸衍生物在制备预防和/或治疗脑中风类疾病药物中的应用。</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2016</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZAh0Sy0qzclMVkhMzkxRSEktyixLLMksSy3WUSgoSi1ILALy8vMUEvNSFBILCoAKIfz8NIU0HBp5GFjTEnOKU3mhNDeDoptriLOHbmpBfnxqcUFicmpeakm8s5-hgamZpbGZhaWjMTFqAO_wOAU</recordid><startdate>20160622</startdate><enddate>20160622</enddate><creator>JIA JIA</creator><creator>SUN YINXING</creator><creator>LI YUYAO</creator><creator>CHENG JIAN</creator><creator>AO GUIZHEN</creator><scope>EVB</scope></search><sort><creationdate>20160622</creationdate><title>Ferulic acid derivatives, preparation and application of ferulic acid derivatives</title><author>JIA JIA ; SUN YINXING ; LI YUYAO ; CHENG JIAN ; AO GUIZHEN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN105693689A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2016</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>JIA JIA</creatorcontrib><creatorcontrib>SUN YINXING</creatorcontrib><creatorcontrib>LI YUYAO</creatorcontrib><creatorcontrib>CHENG JIAN</creatorcontrib><creatorcontrib>AO GUIZHEN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>JIA JIA</au><au>SUN YINXING</au><au>LI YUYAO</au><au>CHENG JIAN</au><au>AO GUIZHEN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Ferulic acid derivatives, preparation and application of ferulic acid derivatives</title><date>2016-06-22</date><risdate>2016</risdate><abstract>The invention provides ferulic acid derivatives adopting a structure shown in formula I or formula II. Starting from the mechanism of various mechanisms causing brain injury after cerebral stroke and the action of ferulic acid in treatment of the cerebral stroke, alkane is taken as a joint arm, ADT-OH (5-(4-hydroxyphenyl)-3H-1,2-dithiole-3-thione) and ferulic acid are connected through ether linkage and ester linkage, and the ferulic acid derivatives are obtained. The invention further provides the application of the ferulic acid derivatives in preparation of drugs for preventing and/or treating cerebral stroke diseases.
本发明提供了种阿魏酸衍生物，具有式I或式II所示的结构，本发明从脑卒中后多种机制导致脑损伤的机理和阿魏酸在治疗脑中风中的作用出发，以烷烃为连接臂，将5-对羟基苯基-3H-1,2-二硫杂环戊烯-3-硫酮(ADT-OH)与阿魏酸通过醚键、酯键相连，得到阿魏酸衍生物。因而，本发明还提供了该阿魏酸衍生物在制备预防和/或治疗脑中风类疾病药物中的应用。</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Ferulic acid derivatives, preparation and application of ferulic acid derivatives |
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