Application of resveratrol in preparation of antidepressant
The invention relates to application of resveratrol in preparation of an antidepressant, and belongs to the field of medicament. A mouse depression model is built through chronic mild stress stimulation, the resveratrol is forcedly fed and given to a mouse, the anti-depression activity of the resver...
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| creator | WANG JIA HU TIANYUAN WANG YUCONG WANG YU ZHANG WEINING FANG QIUJUE WANG CHUNYAN ZHANG YIYUAN FENG SIYI WANG YANHONG ZHENG WEI |
| description | The invention relates to application of resveratrol in preparation of an antidepressant, and belongs to the field of medicament. A mouse depression model is built through chronic mild stress stimulation, the resveratrol is forcedly fed and given to a mouse, the anti-depression activity of the resveratrol is evaluated through a beginning activity test, an elevated plus maze test, a social interference test, a forced swimming test and a tail suspension test, and possible mechanism of the resveratrol is detected through molecular biology and electron microscopy. A result shows that the resveratrol can be used for reversing behavioral manifestations, such as fatigue, depression and decreased social ability, which accompany depression, the behavioral manifestations accompany increment of hippocampus SIRT1 (Silent Information Regulator Factor 1) and PGC (Primordial Germ Cell)-1 alpha protein expression and improvement of the integrity of a hippocampal myelin film structure of the mouse, the destroy which is induced |
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| subjects | HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Application of resveratrol in preparation of antidepressant |
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