Method of refining valsartan comprising more than 10% d-isomers

The present invention relates to a method of refining valsartan comprising more than 10% D-isomers, the method comprising: adding a solvent to valsartan comprising more than 10% D-isomers and dissolving, adding a certain amount of inorganic base, separating solids out after salification, obtaining the filtrate after filtering, and distilling the filtrate to remove the organic solvent; adjusting the pH of the filtrate, extracting with an organic solvent, concentrating most of the organic solvent, cooling to crystallize, and obtaining the product. The method enables the isomers of the product to be below 0.5%, and produces a yield of more than 40%, being suitable for industrial production. 本发明涉及一种含10％以上D型异构体的缬沙坦的精制方法，该方法包括在含10％以上D型异构体的缬沙坦中加入溶剂溶解，然后加入一定量的无机碱，成盐后有固体析出，过滤后得到滤液，滤液蒸除掉有机溶剂；滤液调酸，使用有机溶剂提取，浓缩大部分有机溶剂后，冷却析晶，得到产品。使用该方法可使产品异构体为0.5％以下，收率高达40％以上，适合工业化生产。