Sorafenib compound
The invention relates to a sorafenib compound and a preparation method of an intermediate 4-(4-aminophenoxy)-N-methyl-2-pyridine carboxamide of the sorafenib compound, and belongs to the technical field of medicine preparation. The preparation method comprises the steps that 4-chloro-N-methyl pyridi...
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| creator | WEI WENDENG ZHANG DUQIAN XIE TING BIAN HONGLING HUANG YE |
| description | The invention relates to a sorafenib compound and a preparation method of an intermediate 4-(4-aminophenoxy)-N-methyl-2-pyridine carboxamide of the sorafenib compound, and belongs to the technical field of medicine preparation. The preparation method comprises the steps that 4-chloro-N-methyl pyridine-2-formamide and p-aminophhenol are dissolved into polar organic solvent, a phase transfer catalyst and a solid inorganic base carrier are added, after a heating reflux reaction is complete, hot filtration is performed by adding a filter aid, and a crude product is recrystallized through ethyl acetate and methylbenzene or isopropanol to obtain a pure product. The problems that in the prior art, when 4-(4-aminophenoxy)-N-methyl-2-pyridine carboxamide is prepared, operation is inconvenient, the general reaction time is too long, the yield and the purity are low, and the cost is high are solved. Accordingly, operation is easy, convenient and safe, the reaction time is short, the pure product with the higher purity a |
| format | Patent |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY |
| title | Sorafenib compound |
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