Chimeric antigen receptor-modified immunologic effector cell with PD-L1 blocking agent

Chimeric antigen receptor-modified immunologic effector cell with PD-L1 blocking agent

The invention relates to a chimeric antigen receptor-modified immunologic effector cell with a PD-L1 blocking agent, and further provides a method for secretory expression of programmed death-ligand 1(PD-L1) blocking agent by using the chimeric antigen receptor-modified immunologic effector cell as...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: LI ZONGHAI, WANG PENG, SHI ZHIMIN, SONG BO, PAN ZEYAN
Format: Patent
Sprache:eng
Schlagworte:
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SPIRITS
VINEGAR
WINE
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Beschreibung
Zusammenfassung:The invention relates to a chimeric antigen receptor-modified immunologic effector cell with a PD-L1 blocking agent, and further provides a method for secretory expression of programmed death-ligand 1(PD-L1) blocking agent by using the chimeric antigen receptor-modified immunologic effector cell as a carrier. The anti-tumor effect of the chimeric antigen receptor-modified immunologic effector cell is improved.