Preparation method for stepholidine and derivatives thereof

Preparation method for stepholidine and derivatives thereof

The invention provides a preparation method for stopholidine and derivatives thereof. Specifically, the method comprises the following steps: with a chemical compound as shown in a formula A as an intermediate, carrying out B-N cyclization/sodium borohydride reduction reaction and cyclization reacti...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: YANG YUSHE, GAO SUO
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page
container_issue
container_start_page
container_title
container_volume
creator YANG YUSHE
GAO SUO
description The invention provides a preparation method for stopholidine and derivatives thereof. Specifically, the method comprises the following steps: with a chemical compound as shown in a formula A as an intermediate, carrying out B-N cyclization/sodium borohydride reduction reaction and cyclization reaction so as to obtain a skeleton of a stepholidine compound, wherein definitions of all groups are described in the specification. The method provided by the invention has the advantages of simple operation of related reactions, high yield, cheap reagents, and facilitation to enlargement of the preparation method for methylphenethylamine compounds as shown in a general formula I, and specifically for o-bromobenzeneacetic acid compounds corresponding to 9,10-substituted modes, so the method is applicable to large-scale preparation for optically pure stepholidine or the derivatives thereof.
format Patent
fullrecord <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_CN105294675A</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>CN105294675A</sourcerecordid><originalsourceid>FETCH-epo_espacenet_CN105294675A3</originalsourceid><addsrcrecordid>eNrjZLAOKEotSCxKLMnMz1PITS3JyE9RSMsvUiguSS3IyM_JTMnMS1VIzEtRSEktyiwDKitLLVYoyUgtSs1P42FgTUvMKU7lhdLcDIpuriHOHrqpBfnxqcUFicmpeakl8c5-hgamRpYmZuamjsbEqAEA890wCw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>Preparation method for stepholidine and derivatives thereof</title><source>esp@cenet</source><creator>YANG YUSHE ; GAO SUO</creator><creatorcontrib>YANG YUSHE ; GAO SUO</creatorcontrib><description>The invention provides a preparation method for stopholidine and derivatives thereof. Specifically, the method comprises the following steps: with a chemical compound as shown in a formula A as an intermediate, carrying out B-N cyclization/sodium borohydride reduction reaction and cyclization reaction so as to obtain a skeleton of a stepholidine compound, wherein definitions of all groups are described in the specification. The method provided by the invention has the advantages of simple operation of related reactions, high yield, cheap reagents, and facilitation to enlargement of the preparation method for methylphenethylamine compounds as shown in a general formula I, and specifically for o-bromobenzeneacetic acid compounds corresponding to 9,10-substituted modes, so the method is applicable to large-scale preparation for optically pure stepholidine or the derivatives thereof.</description><language>eng</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>2016</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=20160203&amp;DB=EPODOC&amp;CC=CN&amp;NR=105294675A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=20160203&amp;DB=EPODOC&amp;CC=CN&amp;NR=105294675A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>YANG YUSHE</creatorcontrib><creatorcontrib>GAO SUO</creatorcontrib><title>Preparation method for stepholidine and derivatives thereof</title><description>The invention provides a preparation method for stopholidine and derivatives thereof. Specifically, the method comprises the following steps: with a chemical compound as shown in a formula A as an intermediate, carrying out B-N cyclization/sodium borohydride reduction reaction and cyclization reaction so as to obtain a skeleton of a stepholidine compound, wherein definitions of all groups are described in the specification. The method provided by the invention has the advantages of simple operation of related reactions, high yield, cheap reagents, and facilitation to enlargement of the preparation method for methylphenethylamine compounds as shown in a general formula I, and specifically for o-bromobenzeneacetic acid compounds corresponding to 9,10-substituted modes, so the method is applicable to large-scale preparation for optically pure stepholidine or the derivatives thereof.</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2016</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLAOKEotSCxKLMnMz1PITS3JyE9RSMsvUiguSS3IyM_JTMnMS1VIzEtRSEktyiwDKitLLVYoyUgtSs1P42FgTUvMKU7lhdLcDIpuriHOHrqpBfnxqcUFicmpeakl8c5-hgamRpYmZuamjsbEqAEA890wCw</recordid><startdate>20160203</startdate><enddate>20160203</enddate><creator>YANG YUSHE</creator><creator>GAO SUO</creator><scope>EVB</scope></search><sort><creationdate>20160203</creationdate><title>Preparation method for stepholidine and derivatives thereof</title><author>YANG YUSHE ; GAO SUO</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN105294675A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2016</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>YANG YUSHE</creatorcontrib><creatorcontrib>GAO SUO</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>YANG YUSHE</au><au>GAO SUO</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Preparation method for stepholidine and derivatives thereof</title><date>2016-02-03</date><risdate>2016</risdate><abstract>The invention provides a preparation method for stopholidine and derivatives thereof. Specifically, the method comprises the following steps: with a chemical compound as shown in a formula A as an intermediate, carrying out B-N cyclization/sodium borohydride reduction reaction and cyclization reaction so as to obtain a skeleton of a stepholidine compound, wherein definitions of all groups are described in the specification. The method provided by the invention has the advantages of simple operation of related reactions, high yield, cheap reagents, and facilitation to enlargement of the preparation method for methylphenethylamine compounds as shown in a general formula I, and specifically for o-bromobenzeneacetic acid compounds corresponding to 9,10-substituted modes, so the method is applicable to large-scale preparation for optically pure stepholidine or the derivatives thereof.</abstract><oa>free_for_read</oa></addata></record>
fulltext fulltext_linktorsrc
identifier
ispartof
issn
language eng
recordid cdi_epo_espacenet_CN105294675A
source esp@cenet
subjects ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
title Preparation method for stepholidine and derivatives thereof
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-28T12%3A01%3A12IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=YANG%20YUSHE&rft.date=2016-02-03&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3ECN105294675A%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true