Synthetic method for 5-methyluridine
The invention discloses a synthetic method for 5-methyluridine. The synthetic method is optimized based on a 5-methyluridine chemical synthesis method; the key points are that a byproduct trimethylsilyl acetate in a condensation reaction is separated, and reacts with ammonia to generate hexamethyldi...
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| creator | LIU XIANGHONG LYU GUOFENG ZHANG JIANPING HAN LUBIN HUANG GUODONG GUAN MINXIA |
| description | The invention discloses a synthetic method for 5-methyluridine. The synthetic method is optimized based on a 5-methyluridine chemical synthesis method; the key points are that a byproduct trimethylsilyl acetate in a condensation reaction is separated, and reacts with ammonia to generate hexamethyldisilazane which can be repeatedly utilized; meanwhile, tail gas generated by the reaction is absorbed by absolute methanol to obtain aminomethanol, which can be used in an alcoholysis reaction during the synthesis of 5-methyluridine. The synthetic method for 5-methyluridine provided by the invention combines the advantages of the 5-methyluridine chemical synthesis method and optimizes the defects in production, so that on one hand, a utilization rate of a trisilicane protective group is increased, on the other hand, emission of waste liquor and waste gas is reduced, thereby overcoming the defect that the chemical synthesis method is not environment-friendly while being free of affecting the total yield. |
| format | Patent |
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The synthetic method is optimized based on a 5-methyluridine chemical synthesis method; the key points are that a byproduct trimethylsilyl acetate in a condensation reaction is separated, and reacts with ammonia to generate hexamethyldisilazane which can be repeatedly utilized; meanwhile, tail gas generated by the reaction is absorbed by absolute methanol to obtain aminomethanol, which can be used in an alcoholysis reaction during the synthesis of 5-methyluridine. The synthetic method for 5-methyluridine provided by the invention combines the advantages of the 5-methyluridine chemical synthesis method and optimizes the defects in production, so that on one hand, a utilization rate of a trisilicane protective group is increased, on the other hand, emission of waste liquor and waste gas is reduced, thereby overcoming the defect that the chemical synthesis method is not environment-friendly while being free of affecting the total yield.</description><language>eng</language><subject>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM ; CHEMISTRY ; CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION ORPROCESSING OF GOODS ; DERIVATIVES THEREOF ; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC ; GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS ; METALLURGY ; NUCLEIC ACIDS ; NUCLEOSIDES ; NUCLEOTIDES ; ORGANIC CHEMISTRY ; SUGARS ; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS ; TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE</subject><creationdate>2016</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20160113&DB=EPODOC&CC=CN&NR=105237601A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20160113&DB=EPODOC&CC=CN&NR=105237601A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>LIU XIANGHONG</creatorcontrib><creatorcontrib>LYU GUOFENG</creatorcontrib><creatorcontrib>ZHANG JIANPING</creatorcontrib><creatorcontrib>HAN LUBIN</creatorcontrib><creatorcontrib>HUANG GUODONG</creatorcontrib><creatorcontrib>GUAN MINXIA</creatorcontrib><title>Synthetic method for 5-methyluridine</title><description>The invention discloses a synthetic method for 5-methyluridine. 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The synthetic method for 5-methyluridine provided by the invention combines the advantages of the 5-methyluridine chemical synthesis method and optimizes the defects in production, so that on one hand, a utilization rate of a trisilicane protective group is increased, on the other hand, emission of waste liquor and waste gas is reduced, thereby overcoming the defect that the chemical synthesis method is not environment-friendly while being free of affecting the total yield.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION ORPROCESSING OF GOODS DERIVATIVES THEREOF GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY SUGARS TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE |
| title | Synthetic method for 5-methyluridine |
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