Multi-targeting antitumor composite preparation and preparation method thereof

The invention discloses a multi-targeting antitumor composite preparation and a preparation method thereof. The multi-targeting antitumor composite preparation comprises a Fu vesicle suspension, DOX-BSA and FA-DOX. A vesicle administration system is prepared through integrating immunotherapy, positi...

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Hauptverfasser: DENG ANPING, YAO FENGFENG, ZHAO CHENGLONG, YANG HONG, GONG ZHUPING, LIU DI, LYU XIAOYAN, FU PEI, WANG XUE
Format: Patent
Sprache:eng
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Zusammenfassung:The invention discloses a multi-targeting antitumor composite preparation and a preparation method thereof. The multi-targeting antitumor composite preparation comprises a Fu vesicle suspension, DOX-BSA and FA-DOX. A vesicle administration system is prepared through integrating immunotherapy, positive targeting chemotherapy medicine drug molecules and a passive targeting administration system realize in order to realize low toxicity and high efficiency treatment of tumors, and the vesicle administration system can obviously slowly release Fu to effectively containment tumor development and has small influences on tumor bearing bodies; a newly synthesized immunogen can obtain an antibody with high sensitivity, so foundation is laid for formation of an immune compound macromolecule required by immunotherapy; and the micro-molecular compound FA-DOX has a molecule bridging effect in immunotherapy to promote formation of the immune compound macromolecule. The composite preparation has obviously better curative effects than simple particle administration chemical treatment or simple immunotherapy, has obviously low toxicity, can improve the antitumor effect, and is an anticancer composite preparation with wide research and application prospect.