Process for producing gougerotin employing streptomyces microflavus strains
The present invention relates to novel strains of Streptomyces microflavus and methods of their use for controlling diseases or pests of a plant. The invention also relates to a fermentation broth obtained by cultivating a gougerotin producing Streptomyces strain, wherein the fermentation broth cont...
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| creator | GUAN SHAOHUA ROYALTY REED NATHAN ZHU HONG SALAZAR GERARDO BUENO TAYLOR COLLEEN GUILHABERT-GOYA MAGALIE JOO DANIEL M SMITH FRISBY DAVIS SESIN DAVID CAMPBELL BRIAN CURTIS DAMIAN LU TARA MARGOLIS JONATHAN S |
| description | The present invention relates to novel strains of Streptomyces microflavus and methods of their use for controlling diseases or pests of a plant. The invention also relates to a fermentation broth obtained by cultivating a gougerotin producing Streptomyces strain, wherein the fermentation broth contains at least about 1 g/L gougerotin. The invention also relates to a method of producing a fermentation broth of a gougerotin producing Streptomyces strain, wherein the fermentation broth contains at least about 1 g/L gougerotin, the method comprising cultivating the Streptomyces strain in a culture medium containing a digestible carbon source and a digestible nitrogen source under aerobic conditions, wherein the culture medium contains an amino acid at a concentration effective to achieve a gougerotin concentration of at least 1 g/L. The present disclosure also relates to the molecular cloning of a gougerotin biosynthetic gene cluster from Streptomyces microflavus, and identification of individual genes in the gene cluster as well as the proteins encoded thereby. A gougerotin gene cluster comprising 13 open reading frames (ORFs) is located within a genetic locus of Streptomyces microflavus. |
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| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_CN104968794A</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>CN104968794A</sourcerecordid><originalsourceid>FETCH-epo_espacenet_CN104968794A3</originalsourceid><addsrcrecordid>eNrjZPAOKMpPTi0uVkjLL1IoKMpPKU3OzEtXSM8vTU8tyi_JzFNIzS3Iya8ECRaXFKUWlOTnVgI1KORmJhflp-UklpUWgyQSM_OKeRhY0xJzilN5oTQ3g6Kba4izh25qQX58anFBYnJqXmpJvLOfoYGJpZmFuaWJozExagAYdjcb</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>Process for producing gougerotin employing streptomyces microflavus strains</title><source>esp@cenet</source><creator>GUAN SHAOHUA ; ROYALTY REED NATHAN ; ZHU HONG ; SALAZAR GERARDO BUENO ; TAYLOR COLLEEN ; GUILHABERT-GOYA MAGALIE ; JOO DANIEL M ; SMITH FRISBY DAVIS ; SESIN DAVID ; CAMPBELL BRIAN ; CURTIS DAMIAN ; LU TARA ; MARGOLIS JONATHAN S</creator><creatorcontrib>GUAN SHAOHUA ; ROYALTY REED NATHAN ; ZHU HONG ; SALAZAR GERARDO BUENO ; TAYLOR COLLEEN ; GUILHABERT-GOYA MAGALIE ; JOO DANIEL M ; SMITH FRISBY DAVIS ; SESIN DAVID ; CAMPBELL BRIAN ; CURTIS DAMIAN ; LU TARA ; MARGOLIS JONATHAN S</creatorcontrib><description>The present invention relates to novel strains of Streptomyces microflavus and methods of their use for controlling diseases or pests of a plant. The invention also relates to a fermentation broth obtained by cultivating a gougerotin producing Streptomyces strain, wherein the fermentation broth contains at least about 1 g/L gougerotin. The invention also relates to a method of producing a fermentation broth of a gougerotin producing Streptomyces strain, wherein the fermentation broth contains at least about 1 g/L gougerotin, the method comprising cultivating the Streptomyces strain in a culture medium containing a digestible carbon source and a digestible nitrogen source under aerobic conditions, wherein the culture medium contains an amino acid at a concentration effective to achieve a gougerotin concentration of at least 1 g/L. The present disclosure also relates to the molecular cloning of a gougerotin biosynthetic gene cluster from Streptomyces microflavus, and identification of individual genes in the gene cluster as well as the proteins encoded thereby. A gougerotin gene cluster comprising 13 open reading frames (ORFs) is located within a genetic locus of Streptomyces microflavus.</description><language>eng</language><subject>AGRICULTURE ; ANIMAL HUSBANDRY ; BEER ; BIOCHEMISTRY ; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES ; CHEMISTRY ; DERIVATIVES THEREOF ; ENZYMOLOGY ; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE ; FISHING ; FORESTRY ; HUMAN NECESSITIES ; HUNTING ; METALLURGY ; MICROBIOLOGY ; MUTATION OR GENETIC ENGINEERING ; NUCLEIC ACIDS ; NUCLEOSIDES ; NUCLEOTIDES ; ORGANIC CHEMISTRY ; PEST REPELLANTS OR ATTRACTANTS ; PLANT GROWTH REGULATORS ; PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF ; SPIRITS ; SUGARS ; TRAPPING ; VINEGAR ; WINE</subject><creationdate>2015</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20151007&DB=EPODOC&CC=CN&NR=104968794A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25563,76318</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20151007&DB=EPODOC&CC=CN&NR=104968794A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>GUAN SHAOHUA</creatorcontrib><creatorcontrib>ROYALTY REED NATHAN</creatorcontrib><creatorcontrib>ZHU HONG</creatorcontrib><creatorcontrib>SALAZAR GERARDO BUENO</creatorcontrib><creatorcontrib>TAYLOR COLLEEN</creatorcontrib><creatorcontrib>GUILHABERT-GOYA MAGALIE</creatorcontrib><creatorcontrib>JOO DANIEL M</creatorcontrib><creatorcontrib>SMITH FRISBY DAVIS</creatorcontrib><creatorcontrib>SESIN DAVID</creatorcontrib><creatorcontrib>CAMPBELL BRIAN</creatorcontrib><creatorcontrib>CURTIS DAMIAN</creatorcontrib><creatorcontrib>LU TARA</creatorcontrib><creatorcontrib>MARGOLIS JONATHAN S</creatorcontrib><title>Process for producing gougerotin employing streptomyces microflavus strains</title><description>The present invention relates to novel strains of Streptomyces microflavus and methods of their use for controlling diseases or pests of a plant. The invention also relates to a fermentation broth obtained by cultivating a gougerotin producing Streptomyces strain, wherein the fermentation broth contains at least about 1 g/L gougerotin. The invention also relates to a method of producing a fermentation broth of a gougerotin producing Streptomyces strain, wherein the fermentation broth contains at least about 1 g/L gougerotin, the method comprising cultivating the Streptomyces strain in a culture medium containing a digestible carbon source and a digestible nitrogen source under aerobic conditions, wherein the culture medium contains an amino acid at a concentration effective to achieve a gougerotin concentration of at least 1 g/L. The present disclosure also relates to the molecular cloning of a gougerotin biosynthetic gene cluster from Streptomyces microflavus, and identification of individual genes in the gene cluster as well as the proteins encoded thereby. A gougerotin gene cluster comprising 13 open reading frames (ORFs) is located within a genetic locus of Streptomyces microflavus.</description><subject>AGRICULTURE</subject><subject>ANIMAL HUSBANDRY</subject><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES</subject><subject>CHEMISTRY</subject><subject>DERIVATIVES THEREOF</subject><subject>ENZYMOLOGY</subject><subject>FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE</subject><subject>FISHING</subject><subject>FORESTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HUNTING</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>NUCLEIC ACIDS</subject><subject>NUCLEOSIDES</subject><subject>NUCLEOTIDES</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEST REPELLANTS OR ATTRACTANTS</subject><subject>PLANT GROWTH REGULATORS</subject><subject>PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF</subject><subject>SPIRITS</subject><subject>SUGARS</subject><subject>TRAPPING</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2015</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZPAOKMpPTi0uVkjLL1IoKMpPKU3OzEtXSM8vTU8tyi_JzFNIzS3Iya8ECRaXFKUWlOTnVgI1KORmJhflp-UklpUWgyQSM_OKeRhY0xJzilN5oTQ3g6Kba4izh25qQX58anFBYnJqXmpJvLOfoYGJpZmFuaWJozExagAYdjcb</recordid><startdate>20151007</startdate><enddate>20151007</enddate><creator>GUAN SHAOHUA</creator><creator>ROYALTY REED NATHAN</creator><creator>ZHU HONG</creator><creator>SALAZAR GERARDO BUENO</creator><creator>TAYLOR COLLEEN</creator><creator>GUILHABERT-GOYA MAGALIE</creator><creator>JOO DANIEL M</creator><creator>SMITH FRISBY DAVIS</creator><creator>SESIN DAVID</creator><creator>CAMPBELL BRIAN</creator><creator>CURTIS DAMIAN</creator><creator>LU TARA</creator><creator>MARGOLIS JONATHAN S</creator><scope>EVB</scope></search><sort><creationdate>20151007</creationdate><title>Process for producing gougerotin employing streptomyces microflavus strains</title><author>GUAN SHAOHUA ; ROYALTY REED NATHAN ; ZHU HONG ; SALAZAR GERARDO BUENO ; TAYLOR COLLEEN ; GUILHABERT-GOYA MAGALIE ; JOO DANIEL M ; SMITH FRISBY DAVIS ; SESIN DAVID ; CAMPBELL BRIAN ; CURTIS DAMIAN ; LU TARA ; MARGOLIS JONATHAN S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN104968794A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2015</creationdate><topic>AGRICULTURE</topic><topic>ANIMAL HUSBANDRY</topic><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES</topic><topic>CHEMISTRY</topic><topic>DERIVATIVES THEREOF</topic><topic>ENZYMOLOGY</topic><topic>FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE</topic><topic>FISHING</topic><topic>FORESTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HUNTING</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>NUCLEIC ACIDS</topic><topic>NUCLEOSIDES</topic><topic>NUCLEOTIDES</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEST REPELLANTS OR ATTRACTANTS</topic><topic>PLANT GROWTH REGULATORS</topic><topic>PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF</topic><topic>SPIRITS</topic><topic>SUGARS</topic><topic>TRAPPING</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>GUAN SHAOHUA</creatorcontrib><creatorcontrib>ROYALTY REED NATHAN</creatorcontrib><creatorcontrib>ZHU HONG</creatorcontrib><creatorcontrib>SALAZAR GERARDO BUENO</creatorcontrib><creatorcontrib>TAYLOR COLLEEN</creatorcontrib><creatorcontrib>GUILHABERT-GOYA MAGALIE</creatorcontrib><creatorcontrib>JOO DANIEL M</creatorcontrib><creatorcontrib>SMITH FRISBY DAVIS</creatorcontrib><creatorcontrib>SESIN DAVID</creatorcontrib><creatorcontrib>CAMPBELL BRIAN</creatorcontrib><creatorcontrib>CURTIS DAMIAN</creatorcontrib><creatorcontrib>LU TARA</creatorcontrib><creatorcontrib>MARGOLIS JONATHAN S</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>GUAN SHAOHUA</au><au>ROYALTY REED NATHAN</au><au>ZHU HONG</au><au>SALAZAR GERARDO BUENO</au><au>TAYLOR COLLEEN</au><au>GUILHABERT-GOYA MAGALIE</au><au>JOO DANIEL M</au><au>SMITH FRISBY DAVIS</au><au>SESIN DAVID</au><au>CAMPBELL BRIAN</au><au>CURTIS DAMIAN</au><au>LU TARA</au><au>MARGOLIS JONATHAN S</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Process for producing gougerotin employing streptomyces microflavus strains</title><date>2015-10-07</date><risdate>2015</risdate><abstract>The present invention relates to novel strains of Streptomyces microflavus and methods of their use for controlling diseases or pests of a plant. The invention also relates to a fermentation broth obtained by cultivating a gougerotin producing Streptomyces strain, wherein the fermentation broth contains at least about 1 g/L gougerotin. The invention also relates to a method of producing a fermentation broth of a gougerotin producing Streptomyces strain, wherein the fermentation broth contains at least about 1 g/L gougerotin, the method comprising cultivating the Streptomyces strain in a culture medium containing a digestible carbon source and a digestible nitrogen source under aerobic conditions, wherein the culture medium contains an amino acid at a concentration effective to achieve a gougerotin concentration of at least 1 g/L. The present disclosure also relates to the molecular cloning of a gougerotin biosynthetic gene cluster from Streptomyces microflavus, and identification of individual genes in the gene cluster as well as the proteins encoded thereby. A gougerotin gene cluster comprising 13 open reading frames (ORFs) is located within a genetic locus of Streptomyces microflavus.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | AGRICULTURE ANIMAL HUSBANDRY BEER BIOCHEMISTRY BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES CHEMISTRY DERIVATIVES THEREOF ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE FISHING FORESTRY HUMAN NECESSITIES HUNTING METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PEST REPELLANTS OR ATTRACTANTS PLANT GROWTH REGULATORS PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF SPIRITS SUGARS TRAPPING VINEGAR WINE |
| title | Process for producing gougerotin employing streptomyces microflavus strains |
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