Scaffold used for bone injury recovery and having tissue inductive function

A repairing scaffold used for bone injury and having tissue inductive function is prepared by such processes: (A) dissolving icariin and chitosan in an acetic acid solution to prepare a first mixed solution; (B) adding dropwisely the first mixed solution into paraffin oil; (C) when the first mixed s...

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Hauptverfasser: LI WENJIE, LI GEN, WANG JIUNA, ZHEN PING, TANG JUNJIE, QIN WEN, ZHAO LING, ZHAO HONGBIN
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creator LI WENJIE
LI GEN
WANG JIUNA
ZHEN PING
TANG JUNJIE
QIN WEN
ZHAO LING
ZHAO HONGBIN
description A repairing scaffold used for bone injury and having tissue inductive function is prepared by such processes: (A) dissolving icariin and chitosan in an acetic acid solution to prepare a first mixed solution; (B) adding dropwisely the first mixed solution into paraffin oil; (C) when the first mixed solution is added completely, adding a sodium poly phosphate solution and stirring the mixed solution at the same rotation rate, after the sodium poly phosphate solution is added, pouring the mixed solution into a chamber in a die, freezing the die, and vacuum-freeze-drying the mixed solution to obtain a core layer; (D) mixedly dissolving hydroxyapatite, polycaprolactone and collagen in hexafluoroisopropanol, performing electric-spinning to prepare a shell layer; (E) wrapping the core layer by the shell layer, performing genipin crosslinking cleaning to form a composite structure; and (F) freezing the composite structure and vacuum-freeze-drying the composite structure to prepare the repairing scaffold. The repairing scaffold is excellent in degradability and biocompatibility, is free of toxic and side effects and can satisfy the requirements of a tissue engineering material.
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subjects CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES
DISINFECTION, STERILISATION, OR DEODORISATION OF AIR
HUMAN NECESSITIES
HYGIENE
MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES
MEDICAL OR VETERINARY SCIENCE
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL
title Scaffold used for bone injury recovery and having tissue inductive function
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