Freeze-drying process for ganciclovir for injection
The invention provides a freeze-drying process for ganciclovir for injection. The freeze-drying process comprises the following steps: sequentially carrying out pre-freezing, sublimation-drying and desorption drying on a ganciclovir injection liquid, and obtaining a ganciclovir freeze-dried powder i...
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| creator | HUANG SONGSHENG CAO ZHENGCAO LIAO XIAOSHU LIU SICHUAN CHEN YANGLIU GE JUNYOU LU PEIRONG LI QUAN WAN YANGYU XUN ZHONGHUA LIU ZHIJUN CHENG ZHIPENG LI QUANXUE WANG YANG |
| description | The invention provides a freeze-drying process for ganciclovir for injection. The freeze-drying process comprises the following steps: sequentially carrying out pre-freezing, sublimation-drying and desorption drying on a ganciclovir injection liquid, and obtaining a ganciclovir freeze-dried powder injection, wherein the pre-freezing comprises the step of sequentially carrying out first pre-freezing, pressurizing and second pre-freezing on the ganciclovir injection liquid, wherein the first pre-freezing temperature is minus 3 DEG C to 3 DEG C; the pressurizing pressure is 0.1-0.2MPa; and the second pre-freezing temperature is minus 25 DEG C to minus 30 DEG C. The ganciclovir injection liquid is pre-frozen twice; a pressurizing operation is carried out between two pre-freezing procedures, so that the ganciclovir injection liquid is completely crystallized instantly; the residual moisture of the product in the desorption drying process is prevented; the solute transfer time in a liquid medicine is shortened; the upper structure and the lower structure are consistent; the freeze-drying time is greatly shortened; the plumpness of the product appearance is ensured; the tightness of the structure of a freeze-dried product is enhanced; the shrinkage phenomenon of the product is avoided; and the freeze-drying efficiency of the product is improved. |
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The freeze-drying process comprises the following steps: sequentially carrying out pre-freezing, sublimation-drying and desorption drying on a ganciclovir injection liquid, and obtaining a ganciclovir freeze-dried powder injection, wherein the pre-freezing comprises the step of sequentially carrying out first pre-freezing, pressurizing and second pre-freezing on the ganciclovir injection liquid, wherein the first pre-freezing temperature is minus 3 DEG C to 3 DEG C; the pressurizing pressure is 0.1-0.2MPa; and the second pre-freezing temperature is minus 25 DEG C to minus 30 DEG C. The ganciclovir injection liquid is pre-frozen twice; a pressurizing operation is carried out between two pre-freezing procedures, so that the ganciclovir injection liquid is completely crystallized instantly; the residual moisture of the product in the desorption drying process is prevented; the solute transfer time in a liquid medicine is shortened; the upper structure and the lower structure are consistent; the freeze-drying time is greatly shortened; the plumpness of the product appearance is ensured; the tightness of the structure of a freeze-dried product is enhanced; the shrinkage phenomenon of the product is avoided; and the freeze-drying efficiency of the product is improved.</description><language>eng</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2015</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20150603&DB=EPODOC&CC=CN&NR=104666303A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,777,882,25545,76296</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20150603&DB=EPODOC&CC=CN&NR=104666303A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>HUANG SONGSHENG</creatorcontrib><creatorcontrib>CAO ZHENGCAO</creatorcontrib><creatorcontrib>LIAO XIAOSHU</creatorcontrib><creatorcontrib>LIU SICHUAN</creatorcontrib><creatorcontrib>CHEN YANGLIU</creatorcontrib><creatorcontrib>GE JUNYOU</creatorcontrib><creatorcontrib>LU PEIRONG</creatorcontrib><creatorcontrib>LI QUAN</creatorcontrib><creatorcontrib>WAN YANGYU</creatorcontrib><creatorcontrib>XUN ZHONGHUA</creatorcontrib><creatorcontrib>LIU ZHIJUN</creatorcontrib><creatorcontrib>CHENG ZHIPENG</creatorcontrib><creatorcontrib>LI QUANXUE</creatorcontrib><creatorcontrib>WANG YANG</creatorcontrib><title>Freeze-drying process for ganciclovir for injection</title><description>The invention provides a freeze-drying process for ganciclovir for injection. The freeze-drying process comprises the following steps: sequentially carrying out pre-freezing, sublimation-drying and desorption drying on a ganciclovir injection liquid, and obtaining a ganciclovir freeze-dried powder injection, wherein the pre-freezing comprises the step of sequentially carrying out first pre-freezing, pressurizing and second pre-freezing on the ganciclovir injection liquid, wherein the first pre-freezing temperature is minus 3 DEG C to 3 DEG C; the pressurizing pressure is 0.1-0.2MPa; and the second pre-freezing temperature is minus 25 DEG C to minus 30 DEG C. The ganciclovir injection liquid is pre-frozen twice; a pressurizing operation is carried out between two pre-freezing procedures, so that the ganciclovir injection liquid is completely crystallized instantly; the residual moisture of the product in the desorption drying process is prevented; the solute transfer time in a liquid medicine is shortened; the upper structure and the lower structure are consistent; the freeze-drying time is greatly shortened; the plumpness of the product appearance is ensured; the tightness of the structure of a freeze-dried product is enhanced; the shrinkage phenomenon of the product is avoided; and the freeze-drying efficiency of the product is improved.</description><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2015</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZDB2K0pNrUrVTSmqzMxLVygoyk9OLS5WSMsvUkhPzEvOTM7JL8ssAvMz87JSk0sy8_N4GFjTEnOKU3mhNDeDoptriLOHbmpBfnxqcUFicmpeakm8s5-hgYmZmZmxgbGjMTFqABwLLLA</recordid><startdate>20150603</startdate><enddate>20150603</enddate><creator>HUANG SONGSHENG</creator><creator>CAO ZHENGCAO</creator><creator>LIAO XIAOSHU</creator><creator>LIU SICHUAN</creator><creator>CHEN YANGLIU</creator><creator>GE JUNYOU</creator><creator>LU PEIRONG</creator><creator>LI QUAN</creator><creator>WAN YANGYU</creator><creator>XUN ZHONGHUA</creator><creator>LIU ZHIJUN</creator><creator>CHENG ZHIPENG</creator><creator>LI QUANXUE</creator><creator>WANG YANG</creator><scope>EVB</scope></search><sort><creationdate>20150603</creationdate><title>Freeze-drying process for ganciclovir for injection</title><author>HUANG SONGSHENG ; CAO ZHENGCAO ; LIAO XIAOSHU ; LIU SICHUAN ; CHEN YANGLIU ; GE JUNYOU ; LU PEIRONG ; LI QUAN ; WAN YANGYU ; XUN ZHONGHUA ; LIU ZHIJUN ; CHENG ZHIPENG ; LI QUANXUE ; WANG YANG</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN104666303A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2015</creationdate><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>HUANG SONGSHENG</creatorcontrib><creatorcontrib>CAO ZHENGCAO</creatorcontrib><creatorcontrib>LIAO XIAOSHU</creatorcontrib><creatorcontrib>LIU SICHUAN</creatorcontrib><creatorcontrib>CHEN YANGLIU</creatorcontrib><creatorcontrib>GE JUNYOU</creatorcontrib><creatorcontrib>LU PEIRONG</creatorcontrib><creatorcontrib>LI QUAN</creatorcontrib><creatorcontrib>WAN YANGYU</creatorcontrib><creatorcontrib>XUN ZHONGHUA</creatorcontrib><creatorcontrib>LIU ZHIJUN</creatorcontrib><creatorcontrib>CHENG ZHIPENG</creatorcontrib><creatorcontrib>LI QUANXUE</creatorcontrib><creatorcontrib>WANG YANG</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>HUANG SONGSHENG</au><au>CAO ZHENGCAO</au><au>LIAO XIAOSHU</au><au>LIU SICHUAN</au><au>CHEN YANGLIU</au><au>GE JUNYOU</au><au>LU PEIRONG</au><au>LI QUAN</au><au>WAN YANGYU</au><au>XUN ZHONGHUA</au><au>LIU ZHIJUN</au><au>CHENG ZHIPENG</au><au>LI QUANXUE</au><au>WANG YANG</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Freeze-drying process for ganciclovir for injection</title><date>2015-06-03</date><risdate>2015</risdate><abstract>The invention provides a freeze-drying process for ganciclovir for injection. The freeze-drying process comprises the following steps: sequentially carrying out pre-freezing, sublimation-drying and desorption drying on a ganciclovir injection liquid, and obtaining a ganciclovir freeze-dried powder injection, wherein the pre-freezing comprises the step of sequentially carrying out first pre-freezing, pressurizing and second pre-freezing on the ganciclovir injection liquid, wherein the first pre-freezing temperature is minus 3 DEG C to 3 DEG C; the pressurizing pressure is 0.1-0.2MPa; and the second pre-freezing temperature is minus 25 DEG C to minus 30 DEG C. The ganciclovir injection liquid is pre-frozen twice; a pressurizing operation is carried out between two pre-freezing procedures, so that the ganciclovir injection liquid is completely crystallized instantly; the residual moisture of the product in the desorption drying process is prevented; the solute transfer time in a liquid medicine is shortened; the upper structure and the lower structure are consistent; the freeze-drying time is greatly shortened; the plumpness of the product appearance is ensured; the tightness of the structure of a freeze-dried product is enhanced; the shrinkage phenomenon of the product is avoided; and the freeze-drying efficiency of the product is improved.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Freeze-drying process for ganciclovir for injection |
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