Preparation method of 1-(3-aminopropyl)-2-methylimidazole

The invention provides a method for preparing 1-(3-aminopropyl)-2-methylimidazole. The problems that the reaction yield in the prior art is low, the raw material price is expensive, and the chloride and the byproduct chloride produced in the reaction process are used as raw materials capable of poll...

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Bibliographische Detailangaben
Hauptverfasser: ZHANG HONGWU, CHEN TAO, HU JIANJIAN, CHANG PEI, ZHU YONG, WANG XIAOCHUAN, LI PURUI, WANG BIN
Format: Patent
Sprache:eng
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Zusammenfassung:The invention provides a method for preparing 1-(3-aminopropyl)-2-methylimidazole. The problems that the reaction yield in the prior art is low, the raw material price is expensive, and the chloride and the byproduct chloride produced in the reaction process are used as raw materials capable of polluting environment and corroding the device are solved. The preparation method comprises the following steps: by using 2-methylimidazole and acrylonitrile as the raw material, synthesizing 1-cyanoethyl-2-methylimidazole through Michael addition, high-pressure hydrogenating to prepare 1-(3-aminopropyl)-2-methylimidazole through Rainie cobalt catalysis. The method has the advantages that the raw material price is cheap, the reaction process is free form the production of chloride, thereby reducing the environment pollution, and solving the problem that the former process corrodes the device, and the yield is greatly improved in comparison with the literature report. The method provided by the invention is used for synthesizing the 1-(3-aminopropyl)-2-methylimidazole.