2-cyano pyrrolidine compound, and preparation method and application thereof

2-cyano pyrrolidine compound, and preparation method and application thereof

The invention relates to a 2-cyano pyrrolidine compound, and a preparation method and application thereof. The structural formula of the 2-cyano pyrrolidine compound is shown as formula I in the specification, wherein X is one of carbon, nitrogen, oxygen and sulphur; R is one of benzene ring, substi...

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Hauptverfasser: DUAN CHONGGANG, ZHAO SITAI, KONG XIANGYU, FENG GUANGLING, REN YEMING, CAO CHONG
Format: Patent
Sprache:eng
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CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator DUAN CHONGGANG
ZHAO SITAI
KONG XIANGYU
FENG GUANGLING
REN YEMING
CAO CHONG
description The invention relates to a 2-cyano pyrrolidine compound, and a preparation method and application thereof. The structural formula of the 2-cyano pyrrolidine compound is shown as formula I in the specification, wherein X is one of carbon, nitrogen, oxygen and sulphur; R is one of benzene ring, substituted benzene ring, alkyl and heterocyclic ring. The preparation method comprises the following steps: condensing glycine and different substituted aldehyde as the initial materials; hydrolyzing; condensing to obtain a 2-cyano pyrrolidine dipeptidyl peptidase-4 inhibitor for preparing an antidiabetic medicine.
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The structural formula of the 2-cyano pyrrolidine compound is shown as formula I in the specification, wherein X is one of carbon, nitrogen, oxygen and sulphur; R is one of benzene ring, substituted benzene ring, alkyl and heterocyclic ring. 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The structural formula of the 2-cyano pyrrolidine compound is shown as formula I in the specification, wherein X is one of carbon, nitrogen, oxygen and sulphur; R is one of benzene ring, substituted benzene ring, alkyl and heterocyclic ring. The preparation method comprises the following steps: condensing glycine and different substituted aldehyde as the initial materials; hydrolyzing; condensing to obtain a 2-cyano pyrrolidine dipeptidyl peptidase-4 inhibitor for preparing an antidiabetic medicine.</abstract><oa>free_for_read</oa></addata></record>
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title 2-cyano pyrrolidine compound, and preparation method and application thereof
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