New Blonanserin crystal form and preparation method thereof
The present invention discloses a new Blonanserin crystal form and a preparation method thereof, wherein the X-ray diffraction pattern of the crystal is represented by the figure 1. With the crystal form and the preparation method thereof, the product-related substances can be effectively reduced, t...
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| creator | ZHU JUNBIN LU BIN BI ZHONGBAO LIU REN |
| description | The present invention discloses a new Blonanserin crystal form and a preparation method thereof, wherein the X-ray diffraction pattern of the crystal is represented by the figure 1. With the crystal form and the preparation method thereof, the product-related substances can be effectively reduced, the purity can be increased, and the reaction yield can be increased. The product having the crystal form has the increased stability and is easily stored especially in the high temperature and high humidity condition. According to the present invention, with the good chemical property and the stable crystal arrangement, the excellent solubility is provided, such that the satisfied dose accuracy can be achieved during drug preparation so as to increase the product safety and reduce the risk on the patient, therefore, the crystal form is suitable for preparing the stable pharmaceutical formulation. |
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With the crystal form and the preparation method thereof, the product-related substances can be effectively reduced, the purity can be increased, and the reaction yield can be increased. The product having the crystal form has the increased stability and is easily stored especially in the high temperature and high humidity condition. According to the present invention, with the good chemical property and the stable crystal arrangement, the excellent solubility is provided, such that the satisfied dose accuracy can be achieved during drug preparation so as to increase the product safety and reduce the risk on the patient, therefore, the crystal form is suitable for preparing the stable pharmaceutical formulation.</description><language>eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2015</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20150128&DB=EPODOC&CC=CN&NR=104311487A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20150128&DB=EPODOC&CC=CN&NR=104311487A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>ZHU JUNBIN</creatorcontrib><creatorcontrib>LU BIN</creatorcontrib><creatorcontrib>BI ZHONGBAO</creatorcontrib><creatorcontrib>LIU REN</creatorcontrib><title>New Blonanserin crystal form and preparation method thereof</title><description>The present invention discloses a new Blonanserin crystal form and a preparation method thereof, wherein the X-ray diffraction pattern of the crystal is represented by the figure 1. 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According to the present invention, with the good chemical property and the stable crystal arrangement, the excellent solubility is provided, such that the satisfied dose accuracy can be achieved during drug preparation so as to increase the product safety and reduce the risk on the patient, therefore, the crystal form is suitable for preparing the stable pharmaceutical formulation.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2015</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLD2Sy1XcMrJz0vMK04tysxTSC6qLC5JzFFIyy_KVUjMS1EoKEotSCxKLMnMz1PITS3JyE9RKMlILUrNT-NhYE1LzClO5YXS3AyKbq4hzh66qQX58anFBYnJqXmpJfHOfoYGJsaGhiYW5o7GxKgBAMMkL50</recordid><startdate>20150128</startdate><enddate>20150128</enddate><creator>ZHU JUNBIN</creator><creator>LU BIN</creator><creator>BI ZHONGBAO</creator><creator>LIU REN</creator><scope>EVB</scope></search><sort><creationdate>20150128</creationdate><title>New Blonanserin crystal form and preparation method thereof</title><author>ZHU JUNBIN ; LU BIN ; BI ZHONGBAO ; LIU REN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN104311487A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2015</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>ZHU JUNBIN</creatorcontrib><creatorcontrib>LU BIN</creatorcontrib><creatorcontrib>BI ZHONGBAO</creatorcontrib><creatorcontrib>LIU REN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>ZHU JUNBIN</au><au>LU BIN</au><au>BI ZHONGBAO</au><au>LIU REN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>New Blonanserin crystal form and preparation method thereof</title><date>2015-01-28</date><risdate>2015</risdate><abstract>The present invention discloses a new Blonanserin crystal form and a preparation method thereof, wherein the X-ray diffraction pattern of the crystal is represented by the figure 1. 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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | New Blonanserin crystal form and preparation method thereof |
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