Preparation method for abiraterone acetate
The invention discloses a preparation method for abiraterone acetate. The preparation method comprises the following steps: dehydroepiandrosterone acetate and trifluoromethanesulfonic anhydride are subjected to sulfonyl reaction at the presence of an organic base catalyst to obtain a compound expres...
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| creator | DAI XUYONG LI LIWEI WANG XUDONG LI SHAOKUI CHENG SEN CHENG ZHIGANG HE SIYU |
| description | The invention discloses a preparation method for abiraterone acetate. The preparation method comprises the following steps: dehydroepiandrosterone acetate and trifluoromethanesulfonic anhydride are subjected to sulfonyl reaction at the presence of an organic base catalyst to obtain a compound expressed in the formula II shown in the Specification; the compound and 3-pyridine organoboron componud or 3-pyridine organosilicon compound react at the presence of triphenyl phosphine palladium dichloride catalyst to obtain crude product of abiraterone acetate; the crude product is recrystallized in a proton solvent or a non-proton solvent to obtain abiraterone acetate crystal; the crystal is put into a diffluent solvent again to heat for dissolution and then the dissolved crystal is dropwise added to a less diffluent solvent and stirred for crystallizing solids to obtain micro-powder abiraterone acetate; the diffluent solvent is a mixture of more than two of acetone, ethanol and water at will and the less diffluent s |
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The preparation method comprises the following steps: dehydroepiandrosterone acetate and trifluoromethanesulfonic anhydride are subjected to sulfonyl reaction at the presence of an organic base catalyst to obtain a compound expressed in the formula II shown in the Specification; the compound and 3-pyridine organoboron componud or 3-pyridine organosilicon compound react at the presence of triphenyl phosphine palladium dichloride catalyst to obtain crude product of abiraterone acetate; the crude product is recrystallized in a proton solvent or a non-proton solvent to obtain abiraterone acetate crystal; the crystal is put into a diffluent solvent again to heat for dissolution and then the dissolved crystal is dropwise added to a less diffluent solvent and stirred for crystallizing solids to obtain micro-powder abiraterone acetate; the diffluent solvent is a mixture of more than two of acetone, ethanol and water at will and the less diffluent s</description><language>chi ; eng</language><subject>CHEMISTRY ; METALLURGY ; ORGANIC CHEMISTRY ; STEROIDS</subject><creationdate>2014</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20140806&DB=EPODOC&CC=CN&NR=103965282A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,778,883,25547,76298</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20140806&DB=EPODOC&CC=CN&NR=103965282A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>DAI XUYONG</creatorcontrib><creatorcontrib>LI LIWEI</creatorcontrib><creatorcontrib>WANG XUDONG</creatorcontrib><creatorcontrib>LI SHAOKUI</creatorcontrib><creatorcontrib>CHENG SEN</creatorcontrib><creatorcontrib>CHENG ZHIGANG</creatorcontrib><creatorcontrib>HE SIYU</creatorcontrib><title>Preparation method for abiraterone acetate</title><description>The invention discloses a preparation method for abiraterone acetate. The preparation method comprises the following steps: dehydroepiandrosterone acetate and trifluoromethanesulfonic anhydride are subjected to sulfonyl reaction at the presence of an organic base catalyst to obtain a compound expressed in the formula II shown in the Specification; the compound and 3-pyridine organoboron componud or 3-pyridine organosilicon compound react at the presence of triphenyl phosphine palladium dichloride catalyst to obtain crude product of abiraterone acetate; the crude product is recrystallized in a proton solvent or a non-proton solvent to obtain abiraterone acetate crystal; the crystal is put into a diffluent solvent again to heat for dissolution and then the dissolved crystal is dropwise added to a less diffluent solvent and stirred for crystallizing solids to obtain micro-powder abiraterone acetate; the diffluent solvent is a mixture of more than two of acetone, ethanol and water at will and the less diffluent s</description><subject>CHEMISTRY</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>STEROIDS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2014</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZNAKKEotSCxKLMnMz1PITS3JyE9RSMsvUkhMygQKphbl56UqJCanlgDZPAysaYk5xam8UJqbQdHNNcTZQze1ID8-tbgAqCwvtSTe2c_QwNjSzNTIwsjRmBg1AEvZKUk</recordid><startdate>20140806</startdate><enddate>20140806</enddate><creator>DAI XUYONG</creator><creator>LI LIWEI</creator><creator>WANG XUDONG</creator><creator>LI SHAOKUI</creator><creator>CHENG SEN</creator><creator>CHENG ZHIGANG</creator><creator>HE SIYU</creator><scope>EVB</scope></search><sort><creationdate>20140806</creationdate><title>Preparation method for abiraterone acetate</title><author>DAI XUYONG ; LI LIWEI ; WANG XUDONG ; LI SHAOKUI ; CHENG SEN ; CHENG ZHIGANG ; HE SIYU</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN103965282A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2014</creationdate><topic>CHEMISTRY</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>STEROIDS</topic><toplevel>online_resources</toplevel><creatorcontrib>DAI XUYONG</creatorcontrib><creatorcontrib>LI LIWEI</creatorcontrib><creatorcontrib>WANG XUDONG</creatorcontrib><creatorcontrib>LI SHAOKUI</creatorcontrib><creatorcontrib>CHENG SEN</creatorcontrib><creatorcontrib>CHENG ZHIGANG</creatorcontrib><creatorcontrib>HE SIYU</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>DAI XUYONG</au><au>LI LIWEI</au><au>WANG XUDONG</au><au>LI SHAOKUI</au><au>CHENG SEN</au><au>CHENG ZHIGANG</au><au>HE SIYU</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Preparation method for abiraterone acetate</title><date>2014-08-06</date><risdate>2014</risdate><abstract>The invention discloses a preparation method for abiraterone acetate. The preparation method comprises the following steps: dehydroepiandrosterone acetate and trifluoromethanesulfonic anhydride are subjected to sulfonyl reaction at the presence of an organic base catalyst to obtain a compound expressed in the formula II shown in the Specification; the compound and 3-pyridine organoboron componud or 3-pyridine organosilicon compound react at the presence of triphenyl phosphine palladium dichloride catalyst to obtain crude product of abiraterone acetate; the crude product is recrystallized in a proton solvent or a non-proton solvent to obtain abiraterone acetate crystal; the crystal is put into a diffluent solvent again to heat for dissolution and then the dissolved crystal is dropwise added to a less diffluent solvent and stirred for crystallizing solids to obtain micro-powder abiraterone acetate; the diffluent solvent is a mixture of more than two of acetone, ethanol and water at will and the less diffluent s</abstract><oa>free_for_read</oa></addata></record> |
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| title | Preparation method for abiraterone acetate |
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