Intermediate of rivaroxaban and preparation method thereof

Intermediate of rivaroxaban and preparation method thereof

The invention discloses an intermediate of rivaroxaban and a preparation method thereof. The preparation method comprises the following steps: in a solvent, subjecting a compound II to carry out reactions with a compound III in the presence of an alkali so as to obtain a compound I, wherein the alka...

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Hauptverfasser: JIANG JINGZHANG, ZHOU WEICHENG, WEN YINGLING
Format: Patent
Sprache:chi ; eng
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CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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creator JIANG JINGZHANG
ZHOU WEICHENG
WEN YINGLING
description The invention discloses an intermediate of rivaroxaban and a preparation method thereof. The preparation method comprises the following steps: in a solvent, subjecting a compound II to carry out reactions with a compound III in the presence of an alkali so as to obtain a compound I, wherein the alkali is prepared from C1-C4 alkyl alcohol and alkali metals. The invention also provides a preparation method of a compound IV. The preparation method comprises the following steps: in a solvent, subjecting the compound I to a hydrolysis reaction under an acidic condition so as to obtain the compound IV. The preparation method of intermediate of rivaroxaban has the advantages of available raw materials and low cost, and is capable of being applied to industrial production.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
title Intermediate of rivaroxaban and preparation method thereof
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