Method for preparing 1-[(4-chlorophenyl)methyl]-2-oxo-cyclopentane carboxylate
The invention discloses a method for preparing 1-[(4-chlorophenyl)methyl]-2-oxo-cyclopentane carboxylate. The method comprises the following steps of adding alkali-metal carbonate or alkaline-earth-metal carbonate into an aprotic solvent, adding either methyl 2-oxo-cyclopentanecarboxylate or ethyl 2...
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| creator | JIE YUANPING FAN MANMAN LAI CHUNBO GONG LEI LIAO BENREN YU PENGHAO YUAN ZHENWEN |
| description | The invention discloses a method for preparing 1-[(4-chlorophenyl)methyl]-2-oxo-cyclopentane carboxylate. The method comprises the following steps of adding alkali-metal carbonate or alkaline-earth-metal carbonate into an aprotic solvent, adding either methyl 2-oxo-cyclopentanecarboxylate or ethyl 2-oxo-cyclopentane carboxylate and 4-chlorobenzyl chloride into the aprotic solvent, stirring, carrying out heated reflux reaction for 8-36 hours at normal pressure under the catalysis of iodides, filtering a reaction product after the reaction is completed, and distilling a filtrate to recover the aprotic solvent, thereby obtaining a final product. In the final product, the purity of 1-[(4-chlorophenyl)methyl]-2-oxo-cyclopentane carboxylate is higher than 95%, and the yield is higher than 95%. According to the method, the reaction conditions are mild, the operation is simple, and the prepared product is high in yield and high in purity, so that the development of industrial production is facilitated. |
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The method comprises the following steps of adding alkali-metal carbonate or alkaline-earth-metal carbonate into an aprotic solvent, adding either methyl 2-oxo-cyclopentanecarboxylate or ethyl 2-oxo-cyclopentane carboxylate and 4-chlorobenzyl chloride into the aprotic solvent, stirring, carrying out heated reflux reaction for 8-36 hours at normal pressure under the catalysis of iodides, filtering a reaction product after the reaction is completed, and distilling a filtrate to recover the aprotic solvent, thereby obtaining a final product. In the final product, the purity of 1-[(4-chlorophenyl)methyl]-2-oxo-cyclopentane carboxylate is higher than 95%, and the yield is higher than 95%. 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The method comprises the following steps of adding alkali-metal carbonate or alkaline-earth-metal carbonate into an aprotic solvent, adding either methyl 2-oxo-cyclopentanecarboxylate or ethyl 2-oxo-cyclopentane carboxylate and 4-chlorobenzyl chloride into the aprotic solvent, stirring, carrying out heated reflux reaction for 8-36 hours at normal pressure under the catalysis of iodides, filtering a reaction product after the reaction is completed, and distilling a filtrate to recover the aprotic solvent, thereby obtaining a final product. In the final product, the purity of 1-[(4-chlorophenyl)methyl]-2-oxo-cyclopentane carboxylate is higher than 95%, and the yield is higher than 95%. According to the method, the reaction conditions are mild, the operation is simple, and the prepared product is high in yield and high in purity, so that the development of industrial production is facilitated.</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2014</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZPDzTS3JyE9RSMsvUigoSi1ILMrMS1cw1I3WMNFNzsjJL8ovyEjNq8zRzAWqq8yJ1TXSza_I102uTM7JL0jNK0nMS1VITixKyq-ozEksSeVhYE1LzClO5YXS3AyKbq4hzh66qQX58anFBYnJqXmpJfHOfoYGxqbGlmbmBo7GxKgBANw9Nk0</recordid><startdate>20140129</startdate><enddate>20140129</enddate><creator>JIE YUANPING</creator><creator>FAN MANMAN</creator><creator>LAI CHUNBO</creator><creator>GONG LEI</creator><creator>LIAO BENREN</creator><creator>YU PENGHAO</creator><creator>YUAN ZHENWEN</creator><scope>EVB</scope></search><sort><creationdate>20140129</creationdate><title>Method for preparing 1-[(4-chlorophenyl)methyl]-2-oxo-cyclopentane carboxylate</title><author>JIE YUANPING ; FAN MANMAN ; LAI CHUNBO ; GONG LEI ; LIAO BENREN ; YU PENGHAO ; YUAN ZHENWEN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN103539670A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2014</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>JIE YUANPING</creatorcontrib><creatorcontrib>FAN MANMAN</creatorcontrib><creatorcontrib>LAI CHUNBO</creatorcontrib><creatorcontrib>GONG LEI</creatorcontrib><creatorcontrib>LIAO BENREN</creatorcontrib><creatorcontrib>YU PENGHAO</creatorcontrib><creatorcontrib>YUAN ZHENWEN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>JIE YUANPING</au><au>FAN MANMAN</au><au>LAI CHUNBO</au><au>GONG LEI</au><au>LIAO BENREN</au><au>YU PENGHAO</au><au>YUAN ZHENWEN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Method for preparing 1-[(4-chlorophenyl)methyl]-2-oxo-cyclopentane carboxylate</title><date>2014-01-29</date><risdate>2014</risdate><abstract>The invention discloses a method for preparing 1-[(4-chlorophenyl)methyl]-2-oxo-cyclopentane carboxylate. The method comprises the following steps of adding alkali-metal carbonate or alkaline-earth-metal carbonate into an aprotic solvent, adding either methyl 2-oxo-cyclopentanecarboxylate or ethyl 2-oxo-cyclopentane carboxylate and 4-chlorobenzyl chloride into the aprotic solvent, stirring, carrying out heated reflux reaction for 8-36 hours at normal pressure under the catalysis of iodides, filtering a reaction product after the reaction is completed, and distilling a filtrate to recover the aprotic solvent, thereby obtaining a final product. In the final product, the purity of 1-[(4-chlorophenyl)methyl]-2-oxo-cyclopentane carboxylate is higher than 95%, and the yield is higher than 95%. According to the method, the reaction conditions are mild, the operation is simple, and the prepared product is high in yield and high in purity, so that the development of industrial production is facilitated.</abstract><oa>free_for_read</oa></addata></record> |
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| title | Method for preparing 1-[(4-chlorophenyl)methyl]-2-oxo-cyclopentane carboxylate |
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