Synthesis method of 1-(4-chlorphenyl)-2-cyclopropyl-1-acetone

Synthesis method of 1-(4-chlorphenyl)-2-cyclopropyl-1-acetone

The invention discloses a synthesis method of 1-(4-chlorphenyl)-2-cyclopropyl-1-acetone. The synthesis method comprises the following steps of: with toluene as a solvent, carrying out sufficient reaction on chloropropiophenone and cyclopropyl bromide under the action of a catalyst, and after the rea...

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Hauptverfasser: YAN XIAOHONG, LIU JIE, WEI JUNBO, SHAN MEIQING, ZHAO TINGDONG
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Sprache:chi ; eng
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ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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creator YAN XIAOHONG
LIU JIE
WEI JUNBO
SHAN MEIQING
ZHAO TINGDONG
description The invention discloses a synthesis method of 1-(4-chlorphenyl)-2-cyclopropyl-1-acetone. The synthesis method comprises the following steps of: with toluene as a solvent, carrying out sufficient reaction on chloropropiophenone and cyclopropyl bromide under the action of a catalyst, and after the reaction is finished, adding water to react with the catalyst so as to form an organic-phase and aqueous-phase mixed system after reaction is finished; then standing the mixed system to layer, so that the organic phase and the aqueous phase are separated; and carrying out reduced-pressure rectification on the organic phase, and collecting 120-122DEG C/400Pa fractions to obtain the product, namely, 1-(4-chlorphenyl)-2-cyclopropyl-1-acetone. As no high-toxicity material is used, the synthesis method is simple in technological process, high in safety coefficient, high in conversion per pass, mild in reaction condition, low in environmental pollution and suitable for industrial production.
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The synthesis method comprises the following steps of: with toluene as a solvent, carrying out sufficient reaction on chloropropiophenone and cyclopropyl bromide under the action of a catalyst, and after the reaction is finished, adding water to react with the catalyst so as to form an organic-phase and aqueous-phase mixed system after reaction is finished; then standing the mixed system to layer, so that the organic phase and the aqueous phase are separated; and carrying out reduced-pressure rectification on the organic phase, and collecting 120-122DEG C/400Pa fractions to obtain the product, namely, 1-(4-chlorphenyl)-2-cyclopropyl-1-acetone. 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CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
title Synthesis method of 1-(4-chlorphenyl)-2-cyclopropyl-1-acetone
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