Method of selecting substance characterized by assaying PPAR delta activating effect and drug

The present invention provides a method for screening a substance having a thermogenesis enhancing effect containing a compound having an effect activating PPAR delta, an agent containing the compound, and an agent having antidiabetic, antiobestic or visceral accumulated fat-lowering function. The p...

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Bibliographische Detailangaben
Hauptverfasser:	TAKAGI KENICHIRO, KATAOKA KENICHIRO, CHIKANISHI TOSHIHIRO, YAMAMOTO MASANORI, YAMAOKA KAZUYOSHI
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PHYSICS PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention provides a method for screening a substance having a thermogenesis enhancing effect containing a compound having an effect activating PPAR delta, an agent containing the compound, and an agent having antidiabetic, antiobestic or visceral accumulated fat-lowering function. The present invention provides an agent containing a compound having an effect activating PPAR delta, which is a peroxisome proliferator activated receptor, and having effects which enhances nonshivering thermogenesis (nST), specifically enhances uncoupling respiration in mitochondria of cells in an adipose tissue or the like, or proton leak in inner membranes of mitochondria, and increases the amount of expression of UCP1, and provides an antidiabetic agent, an antiobestic gent and a visceral accumulated fat-lowering agent containing the compound. Further, the present invention provides a method for screening the compound by measuring a PPAR delta activating effect.