Preparation method for carboxymethyl starch sodium

The present invention relates to a preparation method for carboxymethyl starch sodium, and especially to a method for controlling a chloroacetic acid content in the carboxymethyl starch sodium. According to the method, after a carboxymethyl starch sodium sample is produced and dried, an ion chromato...

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Bibliographische Detailangaben
Hauptverfasser:	ZHANG QUNYAN, YANG JING
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	CHEMISTRY COMPOSITIONS BASED THEREON DERIVATIVES THEREOF INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING METALLURGY ORGANIC MACROMOLECULAR COMPOUNDS PHYSICS POLYSACCHARIDES TESTING THEIR PREPARATION OR CHEMICAL WORKING-UP
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Beschreibung
Zusammenfassung:	The present invention relates to a preparation method for carboxymethyl starch sodium, and especially to a method for controlling a chloroacetic acid content in the carboxymethyl starch sodium. According to the method, after a carboxymethyl starch sodium sample is produced and dried, an ion chromatography method is adopted to determine the residue level of the chloroacetic acid in the carboxymethyl starch sodium sample so as to ensure that the content of the residual chloroacetic acid in the carboxymethyl starch sodium is 0-0.05% of the weight of the carboxymethyl starch sodium, wherein an extraction column for treating the sample is an IC-Ag solid-phase extraction column. With the method of the present invention, it is ensured that the residue level of the chloroacetic acid is in a safe range so as to guarantee the drug safety.