Alpha,beta-diamino acid derivative and synthetic method and application thereof
The invention discloses a synthetic method of an alpha, beta-diamino acid derivative. In the method, a one-step reaction is undergone by taking a diazo compound, aniline and aldehyde acid ester as raw materials, taking metal Lewis acid and chiral phosphoric acid as catalysts, taking an organic solve...
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| creator | QIAN YU SUN ZHAOSHUAN ZHOU JING JING CHANGCHENG ZHANG XIA HU WENHAO YANG LIPING |
| description | The invention discloses a synthetic method of an alpha, beta-diamino acid derivative. In the method, a one-step reaction is undergone by taking a diazo compound, aniline and aldehyde acid ester as raw materials, taking metal Lewis acid and chiral phosphoric acid as catalysts, taking an organic solvent as a solvent and taking a 4 Angtrom molecular sieve as a water absorbing agent, so that the alpha, beta-diamino acid derivative is obtained. The synthetic method disclosed by the invention has the advantages of high atom economy, high selectivity and high yield, the reaction conditions are mild, and operation is easy and safe. The alpha, beta-diamino acid derivative has anticancer activity and structural diversity, and is suitable for preparing and applying antitumor, antibiotic and antifungal medicaments. |
| format | Patent |
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In the method, a one-step reaction is undergone by taking a diazo compound, aniline and aldehyde acid ester as raw materials, taking metal Lewis acid and chiral phosphoric acid as catalysts, taking an organic solvent as a solvent and taking a 4 Angtrom molecular sieve as a water absorbing agent, so that the alpha, beta-diamino acid derivative is obtained. The synthetic method disclosed by the invention has the advantages of high atom economy, high selectivity and high yield, the reaction conditions are mild, and operation is easy and safe. 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| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS APPARATUS THEREFOR CHEMISTRY GENERAL METHODS OF ORGANIC CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Alpha,beta-diamino acid derivative and synthetic method and application thereof |
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