Targeting antiglioma protein and application thereof
The invention provides targeting antiglioma protein, wherein on the basis of the approaches (inhabiting the activity of a chloride channel CLC and MMP-2) of experimentally approved scorpion chloride channel neurotoxin (Cltx and BmK CT) in treating brain glioma, an SWISS-MODEL server is utilized for...
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| creator | HUANG RUI WANG WEI FU YUEJUN AN NA LIANG AIHUA YANG RENJIA SHEN QUAN ZHANG ZHIYUN CHAI BAOFENG DU JUN |
| description | The invention provides targeting antiglioma protein, wherein on the basis of the approaches (inhabiting the activity of a chloride channel CLC and MMP-2) of experimentally approved scorpion chloride channel neurotoxin (Cltx and BmK CT) in treating brain glioma, an SWISS-MODEL server is utilized for carrying out the homology modeling of a protein atom structure for the BmK CT, a ZDOCK server is utilized for carrying out the atom structure modeling of a complex of chloride channel toxin and a receptor, a model with stable structure is screened in candidate models, energy minimization and molecular kinetic analysis are carried out, and a novel protein molecular sequence and a model which are optimally designed by using a chloride channel neurotoxin space structure as a framework and have high selectivity and high specificity for antiglioma cells are constructed through analyzing the binding energy and the hydrogen bonding times of the Cltx and the BmK CT. The protein can be used for preparing a medicament for tr |
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| subjects | CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Targeting antiglioma protein and application thereof |
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