Dipropofol dihydrogen pyrophosphate and salt thereof, preparation method and application thereof
The invention discloses dipropofol dihydrogen pyrophosphate and salt thereof, a preparation method and application thereof. Ipropofol serving as a raw material and phosphorus pentoxide undergo reaction in an anhydrous organic solvent, a reaction product is separated and purified to form the dipropof...
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| creator | SUN HONGYI WEI WEN ZOU YONG XIAO CHUNFEN LIU XIANKE |
| description | The invention discloses dipropofol dihydrogen pyrophosphate and salt thereof, a preparation method and application thereof. Ipropofol serving as a raw material and phosphorus pentoxide undergo reaction in an anhydrous organic solvent, a reaction product is separated and purified to form the dipropofol dihydrogen pyrophosphate of formula (2), and the salt of the dipropofol dihydrogen pyrophosphateis any pharmaceutically acceptable salt. The obtained compound can be used for preparing sedative hypnotic and anaesthetic medicaments. The method of the invention has the advantages of simple and convenient operation, easily obtained raw materials, low cost and higher yield. The obtained compound has stable property and good water solubility, can be prepared into various formulations for clinical application, and overcomes many defects of single propofol administration. |
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Ipropofol serving as a raw material and phosphorus pentoxide undergo reaction in an anhydrous organic solvent, a reaction product is separated and purified to form the dipropofol dihydrogen pyrophosphate of formula (2), and the salt of the dipropofol dihydrogen pyrophosphateis any pharmaceutically acceptable salt. The obtained compound can be used for preparing sedative hypnotic and anaesthetic medicaments. The method of the invention has the advantages of simple and convenient operation, easily obtained raw materials, low cost and higher yield. 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Ipropofol serving as a raw material and phosphorus pentoxide undergo reaction in an anhydrous organic solvent, a reaction product is separated and purified to form the dipropofol dihydrogen pyrophosphate of formula (2), and the salt of the dipropofol dihydrogen pyrophosphateis any pharmaceutically acceptable salt. The obtained compound can be used for preparing sedative hypnotic and anaesthetic medicaments. The method of the invention has the advantages of simple and convenient operation, easily obtained raw materials, low cost and higher yield. The obtained compound has stable property and good water solubility, can be prepared into various formulations for clinical application, and overcomes many defects of single propofol administration.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Dipropofol dihydrogen pyrophosphate and salt thereof, preparation method and application thereof |
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