Tgfp-cap peptide and its uses

Tgfp-cap peptide and its uses

The present invention relates to a GFP-CAP peptide having an amino acid sequence derived from TGF- 1 (transforming growth factor- 1) and a cell adhesion sequence, wherein the amino acid sequence derived from TGF- 1 consists of the amino acid sequence of SEQ ID NO:1 and the TGFP-CAP peptide is repres...

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Hauptverfasser: CHO KYOUNG-MI, CHUNG YONG-JI, SONG SANG-SU, KIM JIN-SEUK, CHOI JUN-YOUNG, KIM EUN-MI, KIM YOUNG-DEUG
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CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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creator CHO KYOUNG-MI
CHUNG YONG-JI
SONG SANG-SU
KIM JIN-SEUK
CHOI JUN-YOUNG
KIM EUN-MI
KIM YOUNG-DEUG
description The present invention relates to a GFP-CAP peptide having an amino acid sequence derived from TGF- 1 (transforming growth factor- 1) and a cell adhesion sequence, wherein the amino acid sequence derived from TGF- 1 consists of the amino acid sequence of SEQ ID NO:1 and the TGFP-CAP peptide is represented by the following formula I: Ile-Trp-Ser-Leu-Asp-Thr-Gln-Tyr-Cell adhesion sequence (I). The TGFP-CAP peptide of the present invention exhibits excellent anti-angiogenic activity. In addition, the TGFP-CAP peptide of the present invention prevents effectively melanin generation in skin to have skin whitening effects. The present peptide shows much higher stability and permeability to skin than natural-occurring TGF- 1. Such plausible activities and safety of the present peptide enable advantageously to application to drugs, quasi-drugs and cosmetics.
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subjects CHEMISTRY
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ORGANIC CHEMISTRY
PEPTIDES
title Tgfp-cap peptide and its uses
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